Fungal keratitis: Pathogenesis, diagnosis and prevention

L Niu, X Liu, Z Ma, Y Yin, L Sun, L Yang, Y Zheng - Microbial pathogenesis, 2020 - Elsevier
As a kind of serious, potentially sight-threatening corneal infections with poor prognosis,
fungal keratitis can bring a heavy economic burden to patients and seriously affect the …

The role of IL-6-174 G/C polymorphism and intraocular IL-6 levels in the pathogenesis of ocular diseases: a systematic review and meta-analysis

ZS Ulhaq, GV Soraya, Budu, LR Wulandari - Scientific reports, 2020 - nature.com
Abstract Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and
pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C …

Combination Nanomedicine Strategy for Preventing High-Risk Corneal Transplantation Rejection

T Meng, J Zheng, CS Shin, N Gao, D Bande… - ACS …, 2024 - ACS Publications
High-risk (HR) corneal transplantation presents a formidable challenge, with over 50% of
grafts experiencing rejection despite intensive postoperative care involving frequent topical …

Novel ophthalmic hyaluronic acid-hydrogel with curcumin nanoparticles for enhanced healing of ulcerative keratitis in rabbit model

Z Sohani, S Jamshidi, MK Koohi, J Malakootikhah… - Scientific Reports, 2024 - nature.com
Corneal ulcers, whether melting or indolent, are common in humans and companion
animals. Treatment involves local administration of antibiotic eye drops and corneal healing …

Epithelium-penetrable nanoplatform with enhanced antibiotic internalization for management of bacterial keratitis

Y Zhang, Y Yu, G Li, X Zhang, Z Wu, L Lin - Biomacromolecules, 2021 - ACS Publications
A standardized regimen for addressing the adverse effects of bacterial keratitis on vision
remains an intractable challenge due to poor epithelial penetration and a short corneal …

[HTML][HTML] Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients

CY Tsai, CT Chen, CH Lin, CC Liao, K Hua… - … Journal of Medical …, 2021 - ncbi.nlm.nih.gov
Objectives: Myopia is the most common refractive vision disorder. In recent years, several
studies have suggested that the alteration of the exosomal protein levels in the aqueous …

Ocular surface infection mediated molecular stress responses: A review

S Das, S D'Souza, B Gorimanipalli, R Shetty… - International Journal of …, 2022 - mdpi.com
Infection mediated ocular surface stress responses are activated as early defense
mechanisms in response to host cell damage. Integrated stress responses initiate the host …

Anterior chamber paracentesis during intravitreal injections in observational trials: effectiveness and safety and effects

S Saxena, TY Lai, H Koizumi, ME Farah… - International journal of …, 2019 - Springer
A paracentesis prior to an intravitreal injection is a very safe procedure and can prevent IOP-
spikes after injections. As these spikes pose the risk of inducing glaucomatous changes …

A Pilot Study to Evaluate Genipin in Staphylococcus aureus and Pseudomonas aeruginosa Keratitis Models: Modulation of Pro-Inflammatory Cytokines and Matrix …

M Huertas-Bello, JA Cuéllar-Sáenz… - International Journal of …, 2023 - mdpi.com
Infectious keratitis is a vision-threatening microbial infection. The increasing antimicrobial
resistance and the fact that severe cases often evolve into corneal perforation necessitate …

Enhanced in vivo antifungal activity of novel cell penetrating peptide natamycin conjugate for efficient fungal keratitis management

H Rohira, S Shankar, S Yadav, SG Shah… - International Journal of …, 2021 - Elsevier
Natamycin is the only FDA approved drug that is used as a first line of treatment for fungal
keratitis caused by filamentous fungi, however natamycin is known for poor corneal …