Proline is a multifunctional amino acid that is accumulated in high concentrations in plants
under various stress conditions. Proline accumulation is intimately connected to many …

Autophagy is a process in which cellular components are delivered to lytic vacuoles to be
recycled and has been demonstrated to promote abiotic/biotic stress tolerance. Here, we …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Significance: It is increasingly clear that proline metabolism plays an important role in
metabolic reprogramming, not only in cancer but also in related fields such as aging …

Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and
disabilities of aging, as well as several orphan diseases. 7KC is the most common product of …

Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of
enzymes responding to metabolic stress and participating in metabolic signaling. Collagen …

Autophagy is a catalytic process of the bulk degradation of long‐lived cellular components,
ultimately resulting in lysosomal digestion within mature cytoplasmic compartments known …

Cancer cells often change their metabolism to support uncontrolled proliferation. Proline is
the only proteogenic secondary amino acid that is abundant in the body. Recent studies …

The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

Oxidative stress is a silent participant in all chronic progressive pathology and degenerative
disorders. Neurodegeneration and cognitive impairment are caused by increased …