Evaluating the clinical validity of gene-disease associations: an evidence-based framework developed by the clinical genome resource
With advances in genomic sequencing technology, the number of reported gene-disease
relationships has rapidly expanded. However, the evidence supporting these claims varies …
relationships has rapidly expanded. However, the evidence supporting these claims varies …
Genetic epidemiology of breast cancer in Latin America
The last 10 years witnessed an acceleration of our understanding of what genetic factors
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …
Potential impacts of prebiotics and probiotics on cancer prevention
S Samanta - Anti-Cancer Agents in Medicinal Chemistry …, 2022 - ingentaconnect.com
Background: Cancer is a serious problem throughout the world. The pathophysiology of
cancer is multifactorial and is also related to gut microbiota. Intestinal microbes are the …
cancer is multifactorial and is also related to gut microbiota. Intestinal microbes are the …
[HTML][HTML] DNA damage and breast cancer
JD Davis, SY Lin - World journal of clinical oncology, 2011 - ncbi.nlm.nih.gov
Cancer is intimately related to the accumulation of DNA damage, and repair failures
(including mutation prone repair and hyperactive repair systems). This article relates current …
(including mutation prone repair and hyperactive repair systems). This article relates current …
Germline pathogenic variants impact clinicopathology of advanced lung cancer
Background: The genetic factors that modulate risk for developing lung cancer have not
been fully defined. Here, we sought to determine the prevalence and clinical significance of …
been fully defined. Here, we sought to determine the prevalence and clinical significance of …
Genomic disparities in breast cancer among Latinas
Background Breast cancer is the most common cancer diagnosed among Latinas in the
United States and the leading cause of cancer-related death among this population. Latinas …
United States and the leading cause of cancer-related death among this population. Latinas …
RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies
LB Gao, XM Pan, LJ Li, WB Liang, Y Zhu… - Breast cancer research …, 2011 - Springer
Growing evidence suggests that RAD51 plays a pivotal role in the repair of DNA double-
strand breaks and the maintenance of genomic stability. A single nucleotide polymorphism …
strand breaks and the maintenance of genomic stability. A single nucleotide polymorphism …
Anticarcinogenecity of microbiota and probiotics in breast cancer
Breast cancer is one of the most important causes of cancer related morbidity and mortality
in the world. Along with genetic, environmental factors also play a multifaceted role in the …
in the world. Along with genetic, environmental factors also play a multifaceted role in the …
Correlation between selected XRCC2, XRCC3 and RAD51 gene polymorphisms and primary breast cancer in women in Pakistan
Genetic polymorphisms in homologous recombination repair genes cause an abnormal
development of cancerous cells. In the present study we evaluated the possibility of breast …
development of cancerous cells. In the present study we evaluated the possibility of breast …
Spectrum of BRCA1/2 point mutations and genomic rearrangements in high-risk breast/ovarian cancer Chilean families
P Gonzalez-Hormazabal, S Gutierrez-Enriquez… - Breast cancer research …, 2011 - Springer
The distribution of BRCA1/2 germline mutations in breast/ovarian cancer (BC/OC) families
varies among different populations. In the Chilean population, there are only two reports of …
varies among different populations. In the Chilean population, there are only two reports of …