Although fibrosis is becoming increasingly recognized as a major cause of morbidity and
mortality in chronic inflammatory diseases, available treatment strategies are limited …

In an aging society with common lifestyle-associated health issues such as obesity and
diabetes, chronic wounds pose a frequent challenge that physicians face in everyday …

Background The overproduction of reactive oxygen species (ROS) and exacerbated
inflammatory response are the main events that impair healing of pressure ulcers. Therefore …

Abstract Aims Cyclooxygenase-2 (COX-2) and prostaglandin E 2 (PGE 2) are involved in
chronic inflammation observed in chronic lesions. Nonetheless, neither study demonstrated …

Aims In pressure ulcers, the synthesis of reactive oxygen species induced by ischemia and
reperfusion leads to chronic inflammation and tissue damage, which impair the closure of …

The pressure injury environment is characterized by overproduction of reactive oxygen
species and exacerbated inflammation, which impair the healing of these lesions …

Melatonin (5-methoxy-N-acetylserotonin), the pineal hormone, is also synthesized by
immune-competent cells. The pineal hormone signals darkness, while melatonin …

The aim of this study was to evaluate the effects of photobiomodulation (PBM) by dual-
wavelength low-power lasers on the healing and bacterial bioburden of pressure ulcer (PU) …

Background: The effects of exercise on the innate/inflammatory immune responses are
crucially mediated by catecholamines and adrenoreceptors; and mediations in both …

Mesenchymal stem cells (MSCs) play an important role in cutaneous wound healing;
however, the functional mechanisms involved in the healing process are poorly understood …