A current perspective on snake venom composition and constituent protein families

T Tasoulis, GK Isbister - Archives of toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …

Tissue damaging toxins in snake venoms: Mechanisms of action, pathophysiology and treatment strategies

MA Bittenbinder, J van Thiel, FC Cardoso… - Communications …, 2024 - nature.com
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …

Unveiling the functional epitopes of cobra venom cytotoxin by immunoinformatics and epitope-omic analyses

JJ Hiu, JKY Fung, HS Tan, MKK Yap - Scientific Reports, 2023 - nature.com
Approximate 70% of cobra venom is composed of cytotoxin (CTX), which is responsible for
the dermonecrotic symptoms of cobra envenomation. However, CTX is generally low in …

Current insights in the mechanisms of cobra venom cytotoxins and their complexes in inducing toxicity: implications in antivenom therapy

B Kalita, YN Utkin, AK Mukherjee - Toxins, 2022 - mdpi.com
Cytotoxins (CTXs), an essential class of the non-enzymatic three-finger toxin family, are
ubiquitously present in cobra venoms. These low-molecular-mass toxins, contributing to …

Development of a Monoclonal scFv against Cytotoxin to Neutralize Cytolytic Activity Induced by Naja atra Venom on Myoblast C2C12 Cells

CC Liu, CJ Wu, TY Chou, GW Liaw, YC Hsiao, LJ Chu… - Toxins, 2022 - mdpi.com
The Taiwanese cobra, Naja atra, is a clinically significant species of snake observed in the
wild in Taiwan. Victims bitten by N. atra usually experience severe pain and local tissue …

Proteomic characteristics of six snake venoms from the Viperidae and Elapidae families in China and their relation to local tissue necrosis

WG Qin, ZP Zhuo, H Hu, M Lay, QQ Li, JT Huang… - Toxicon, 2023 - Elsevier
Patients envenomed by snakes from the Viperidae and Elapidae families in China often
have varying degrees of local tissue necrosis. Due to the relative clinical characteristics of …

Design and Application of pH-Responsive Liposomes for Site-Specific Delivery of Cytotoxin from Cobra Venom

Q Lin, Y Jing, C Yan, X Chen, Q Zhang… - International Journal …, 2024 - Taylor & Francis
Background Current immunotherapies with unexpected severe side effects and treatment
resistance have not resulted in the desired outcomes for patients with melanoma, and there …

Cobra Venom Cytotoxins as a Tool for Probing Mechanisms of Mitochondrial Energetics and Understanding Mitochondrial Membrane Structure

ES Gasanoff, RK Dagda - Toxins, 2024 - mdpi.com
In this paper, we provide an overview of mitochondrial bioenergetics and specific conditions
that lead to the formation of non-bilayer structures in mitochondria. Secondly, we provide a …

Specific Amino Acid Residues in the Three Loops of Snake Cytotoxins Determine Their Membrane Activity and Provide a Rationale for a New Classification of These …

PV Dubovskii, YN Utkin - Toxins, 2024 - mdpi.com
Cytotoxins (CTs) are three-finger membrane-active toxins present mainly in cobra venom.
Our analysis of the available CT amino acid sequences, literature data on their membrane …

Clinical study of anti-snake venom blockade in the treatment of local tissue necrosis caused by Chinese cobra (Naja atra) bites

L Zeng, J Hou, C Ge, Y Li, J Gao, C Zhang… - PLOS Neglected …, 2022 - journals.plos.org
Objective This study aimed to evaluate the clinical therapeutic efficacy of anti-snake venom
serum blockade in treating local tissue necrosis caused by Chinese cobra (Naja atra) bites …