The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product
is degraded by the ribosome-mediated quality control (RQC) system. Here we report that …

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place
across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved …

The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in
eukaryotes contain 79–80 proteins and four ribosomal RNAs (rRNAs) more than 5,400 …

During the early stages of human large ribosomal subunit (60 S) biogenesis, an ensemble of
assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S …

Eukaryotic 60S ribosomal subunits are comprised of three rRNAs and∼ 50 ribosomal
proteins. The initial steps of their formation take place in the nucleolus, but, owing to a lack of …

The ribosome, central to protein synthesis in all cells, is a complex multicomponent
assembly with rRNA at its functional core. During the process of ribosome biogenesis …