Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial
enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types …

Genome‐wide transcriptional activity involves the binding of many transcription factors (TFs)
to thousands of sites in the genome. Pioneer TFs are a class of TFs that maintain open …

Cells integrate mechanical cues to direct fate specification to maintain tissue function and
homeostasis. While disruption of these cues is known to lead to aberrant cell behavior and …

X chromosome inactivation (XCI) in mammals is mediated by Xist RNA which functions in cis
to silence genes on a single X chromosome in XX female cells, thereby equalising levels of …

Eukaryotic gene regulation is a combinatorial, dynamic, and quantitative process that plays
a vital role in development and disease and can be modeled at a systems level in gene …

Some epigenetic information can be transmitted between generations without changes in
the underlying DNA sequence. Changes in epigenetic regulators, termed epimutations, can …

Cell plasticity theoretically extends to all possible cell types, but naturally decreases as cells
differentiate, whereas injury-repair re-engages the developmental plasticity. Here we show …

The currently predominant approach to transcriptomic and epigenomic single-cell analysis
depends on a rigid perspective constrained by reduced dimensions and algorithmically …

Cis-regulatory elements (CREs) are pivotal in orchestrating gene expression throughout
diverse biological systems. Accurate identification and in-depth characterization of functional …