Noncoding RNAs in age-related cardiovascular diseases
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the
adult population worldwide and represent a severe economic burden and public health …
adult population worldwide and represent a severe economic burden and public health …
Molecular mechanisms of immunosenescene and inflammaging: relevance to the immunopathogenesis and treatment of multiple sclerosis
O Perdaens, V Van Pesch - Frontiers in neurology, 2022 - frontiersin.org
Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …
senescence involving both innate and adaptive immunity, called immunosenescence and …
GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability
The list of long non-coding RNAs (lncRNAs) involved in the p53 pathway of the DNA
damage response is rapidly expanding, but whether lncRNAs have a role in maintaining the …
damage response is rapidly expanding, but whether lncRNAs have a role in maintaining the …
MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer
R Dinami, L Pompili, E Petti, M Porru… - EMBO Molecular …, 2023 - embopress.org
The telomeric repeat‐binding factor 2 (TRF2) is a telomere‐capping protein that plays a key
role in the maintenance of telomere structure and function. It is highly expressed in different …
role in the maintenance of telomere structure and function. It is highly expressed in different …
[HTML][HTML] The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype
R Wallis, H Mizen, CL Bishop - Mechanisms of ageing and development, 2020 - Elsevier
Senescence is a state of proliferative arrest which has been described as a protective
mechanism against the malignant transformation of cells. However, senescent cells have …
mechanism against the malignant transformation of cells. However, senescent cells have …
Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes
Background Cancer cells become immortalized through telomere maintenance
mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to …
mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to …
Exosomes in ageing and motor neurone disease: biogenesis, uptake mechanisms, modifications in disease and uses in the development of biomarkers and …
E Anakor, L Le Gall, J Dumonceaux, WJ Duddy… - Cells, 2021 - mdpi.com
Intercellular communication between neurons and their surrounding cells occurs through the
secretion of soluble molecules or release of vesicles such as exosomes into the extracellular …
secretion of soluble molecules or release of vesicles such as exosomes into the extracellular …
Human RAP 1 specifically protects telomeres of senescent cells from DNA damage
Abstract Repressor/activator protein 1 (RAP 1) is a highly evolutionarily conserved protein
found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non …
found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non …
Are microRNAs true sensors of ageing and cellular senescence?
All living beings are programmed to death due to aging and age-related processes. Aging is
a normal process of every living species. While all cells are inevitably progressing towards …
a normal process of every living species. While all cells are inevitably progressing towards …
MicroRNAs, aging, cellular senescence, and Alzheimer's disease
Aging is a normal process of living being. It has been reported that multiple cellular changes,
including oxidative damage/mitochondrial dysfunction, telomere shortening, inflammation …
including oxidative damage/mitochondrial dysfunction, telomere shortening, inflammation …