Haematopoietic and immune defects associated with GATA2 mutation
Heterozygous familial or sporadic GATA 2 mutations cause a multifaceted disorder,
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …
The GATA factor revolution in hematology
KR Katsumura, EH Bresnick… - Blood, The Journal …, 2017 - ashpublications.org
The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …
The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
Pioneer transcription factors recognise and bind their target sequences in inaccessible
chromatin to establish new transcriptional networks throughout development and cellular …
chromatin to establish new transcriptional networks throughout development and cellular …
Transcription factor activities enhance markers of drug sensitivity in cancer
Transcriptional dysregulation induced by aberrant transcription factors (TF) is a key feature
of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer …
of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer …
Pioneer factors and ATP‐dependent chromatin remodeling factors interact dynamically: a new perspective: Multiple transcription factors can effect chromatin pioneer …
Transcription factor (TF) signaling regulates gene transcription and requires a complex
network of proteins. This network includes co‐activators, co‐repressors, multiple TFs …
network of proteins. This network includes co‐activators, co‐repressors, multiple TFs …
Chirality controls mesenchymal stem cell lineage diversification through mechanoresponses
Y Wei, S Jiang, M Si, X Zhang, J Liu, Z Wang… - Advanced …, 2019 - Wiley Online Library
Biogenesis and tissue development are based on the heterogenesis of multipotent stem
cells. However, the underlying mechanisms of stem cell fate specification are unclear …
cells. However, the underlying mechanisms of stem cell fate specification are unclear …
A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice
A Rajagopalan, Y Feng, MB Gayatri… - The Journal of …, 2023 - Am Soc Clin Investig
We previously demonstrated that a subset of acute myeloid leukemia (AML) patients with
concurrent RAS pathway and TP53 mutations have an extremely poor prognosis and that …
concurrent RAS pathway and TP53 mutations have an extremely poor prognosis and that …
Role of the pioneer transcription factor GATA2 in health and disease
The transcription factor GATA2 is involved in human diseases ranging from hematopoietic
disorders, to cancer, to infectious diseases. GATA2 is one of six GATA-family transcription …
disorders, to cancer, to infectious diseases. GATA2 is one of six GATA-family transcription …
Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer
The development and function of stem and progenitor cells that produce blood cells are vital
in physiology. GATA-binding protein 2 (GATA2) mutations cause GATA-2 deficiency …
in physiology. GATA-binding protein 2 (GATA2) mutations cause GATA-2 deficiency …
GATA factor-dependent positive-feedback circuit in acute myeloid leukemia cells
KR Katsumura, IM Ong, AW DeVilbiss, R Sanalkumar… - Cell reports, 2016 - cell.com
The master regulatory transcription factor GATA-2 triggers hematopoietic stem and
progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic …
progenitor cell generation. GATA2 haploinsufficiency is implicated in myelodysplastic …