Gut microbiome, liver immunology, and liver diseases

R Wang, R Tang, B Li, X Ma, B Schnabl… - Cellular & molecular …, 2021 - nature.com
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately
connected with human physiology. The liver is a central immunological organ that is …

The microbiota and the gut–liver axis in primary sclerosing cholangitis

JR Hov, TH Karlsen - Nature Reviews Gastroenterology & Hepatology, 2023 - nature.com
Primary sclerosing cholangitis (PSC) offers unique opportunities to explore the gut–liver axis
owing to the close association between liver disease and colonic inflammation. It is well …

The microbiome and autoimmunity: a paradigm from the gut–liver axis

B Li, C Selmi, R Tang, ME Gershwin… - Cellular & molecular …, 2018 - nature.com
Microbial cells significantly outnumber human cells in the body, and the microbial flora at
mucosal sites are shaped by environmental factors and, less intuitively, act on host immune …

The pathogenesis of extraintestinal manifestations: implications for IBD research, diagnosis, and therapy

CRH Hedin, SR Vavricka, AJ Stagg… - Journal of Crohn's …, 2019 - academic.oup.com
This article reports on the sixth scientific workshop of the European Crohn's and Colitis
Organisation [ECCO] on the pathogenesis of extraintestinal manifestations [EIMs] in …

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia

PM Maciocia, PA Wawrzyniecka… - Blood, The Journal …, 2022 - ashpublications.org
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of immature T
lymphocytes, associated with higher rates of induction failure compared with those in B cell …

Chemokines and chemokine receptors as therapeutic targets in inflammatory bowel disease; pitfalls and promise

PJ Trivedi, DH Adams - Journal of Crohn's and Colitis, 2018 - academic.oup.com
The principal targets for anti-chemokine therapy in inflammatory bowel disease (IBD) have
been the receptors CCR9 and CXCR3 and their respective ligands CCL25 and CXCL10 …

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease

R Freire, L Ingano, G Serena, M Cetinbas, A Anselmo… - Scientific reports, 2019 - nature.com
Celiac disease (CD) is an immune-mediated disorder triggered by gluten exposure. The
contribution of the adaptive immune response to CD pathogenesis has been extensively …

[HTML][HTML] The gut-liver axis in immune remodeling: new insight into liver diseases

X Yang, D Lu, J Zhuo, Z Lin, M Yang… - International journal of …, 2020 - ncbi.nlm.nih.gov
The gut microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea,
and protozoans, playing a fundamental role in the induction, training, and function of the …

Higher levels of Bifidobacteria and tumor necrosis factor in children with drug-resistant epilepsy are associated with anti-seizure response to the ketogenic diet

M Dahlin, SS Singleton, JA David, A Basuchoudhary… - …, 2022 - thelancet.com
Background Recently, studies have suggested a role for the gut microbiota in epilepsy. Gut
microbial changes during ketogenic diet (KD) treatment of drug-resistant epilepsy have been …

Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases

SJS Rubin, L Bai, Y Haileselassie, G Garay… - Nature …, 2019 - nature.com
Inflammatory bowel disease (IBD) includes Crohn's disease and ulcerative colitis. Each
disease is characterized by a diverse set of potential manifestations, which determine …