Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability

YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Endothelial/pericyte interactions

A Armulik, A Abramsson, C Betsholtz - Circulation research, 2005 - Am Heart Assoc
Interactions between endothelial cells and mural cells (pericytes and vascular smooth
muscle cells) in the blood vessel wall have recently come into focus as central processes in …

Mechanical tugging force regulates the size of cell–cell junctions

Z Liu, JL Tan, DM Cohen, MT Yang… - Proceedings of the …, 2010 - National Acad Sciences
Actomyosin contractility affects cellular organization within tissues in part through the
generation of mechanical forces at sites of cell–matrix and cell–cell contact. While increased …

VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation

D Vestweber - Arteriosclerosis, thrombosis, and vascular biology, 2008 - Am Heart Assoc
Vascular endothelial (VE)-cadherin is a strictly endothelial specific adhesion molecule
located at junctions between endothelial cells. In analogy of the role of E-cadherin as major …

The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities

FR Millar, C Summers, MJ Griffiths, MR Toshner… - Thorax, 2016 - thorax.bmj.com
The pulmonary endothelium is a dynamic, metabolically active layer of squamous
endothelial cells ideally placed to mediate key processes involved in lung homoeostasis …

Regulation of endothelial junctional permeability

E Vandenbroucke, D Mehta… - Annals of the new …, 2008 - Wiley Online Library
The endothelium is a semi‐permeable barrier that regulates the flux of liquid and solutes,
including plasma proteins, between the blood and surrounding tissue. The permeability of …

Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: Just What It Takes to Make a Blood Vessel

F Moccia, S Negri, M Shekha, P Faris… - International journal of …, 2019 - mdpi.com
It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery

P Qin, T Han, CH Alfred, L Xu - Journal of controlled release, 2018 - Elsevier
Ultrasound-driven microbubbles can trigger reversible membrane perforation
(sonoporation), open interendothelial junctions and stimulate endocytosis, thereby providing …

[PDF][PDF] Sinusoidal remodeling and angiogenesis: a new function for the liver‐specific pericyte?

JS Lee, D Semela, J Iredale, VH Shah - Hepatology, 2007 - Wiley Online Library
Although pericytes were described more than 100 years ago as perivascular cells that wrap
around blood capillaries, the term pericyte (peri, around; cyte, cell) was first introduced by …