To date, nutritional epidemiology has relied heavily on relatively weak methods including
simple observational designs and substandard measurements. Despite low internal validity …

Discussing causes in science, if we are to do so in a way that is sensible, begins at the root.
All too often, we jump to discussing specific postulated causes but do not first consider what …

Levothyroxine (LT4) therapy has a long history, a well-defined pharmacological profile and a
favourable safety record in the alleviation of hypothyroidism. However, questions remain in …

Background In the treatment for hypothyroidism, a historically symptom-orientated approach
has given way to reliance on a single biochemical parameter, thyroid stimulating hormone …

It is increasingly assumed that there is no one‐size‐fits‐all approach to dietary
recommendations for the management and treatment of chronic diseases such as obesity …

Background: For significant numbers of patients dissatisfied on standard levothyroxine (LT4)
treatment for hypothyroidism, patient-specific responses to T4 could play a significant role …

weight management interventions manifest considerable treatment response heterogeneity.
For decades, anti-obesity drug development primarily targeted central neurotransmitters …

The placebo serves as an indispensable control in many randomized trials. When analyzing
the benefit of a new treatment, researchers are often confronted with large placebo effects …

This review provides an overview of examples of especially creative work related to the
fields of ingestive behavior, energetics (defined as the study of the acquisition, storage, and …

Investigators traditionally use randomized designs and corresponding analysis procedures
to make causal inferences about the effects of interventions, assuming independence …