Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …

In the recent past, prevalence of life threatening fungal diseases have increased rapidly in
immune-compromised cases such as acquired immunodeficiency syndrome (AIDS), cancer …

The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit
enhanced antimicrobial activity. Through the attachment of hydrophobic residues such as …

Carbohydrate esters are biodegradable, and the degraded adducts are naturally occurring
carbohydrates and fatty acids which are environmentally friendly and non-toxic to human. A …

Candida spp. are the primary opportunistic pathogens of nosocomial fungal infections,
causing both superficial and life-threatening systemic infections. Combination therapy for …

Growing resistance to antimicrobial medicines is a critical health problem that must be
urgently addressed. Adding to the increasing number of patients that succumb to infections …

Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic
agents available to treat fungi are limited, and there is a critical need for new agents to …

Antimicrobial cationic amphiphiles derived from aminoglycosides act through cell membrane
permeabilization but have limited selectivity for microbial cell membranes. Herein, we report …