Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

Cilia are hair-like projections found on almost all cells in the human body. Originally
believed to function merely in motility, the function of solitary non-motile (primary) cilia was …

Many animal cells assemble single cilia involved in motile and/or sensory functions. In
contrast, multiciliated cells (MCCs) assemble up to 300 motile cilia that beat in a coordinate …

Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial
barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF …

Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating
glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss …

Primary cilia are antenna-like sensory microtubule structures that extend from basal bodies,
plasma membrane–docked mother centrioles. Cellular quiescence potentiates ciliogenesis …

Cerebrospinal fluid (CSF) continuously flows through the cerebral ventricles, a process
essential for brain homeostasis. Multiciliated ependymal (E1) cells line the walls of the …

Centrosomes are dominant microtubule organizing centers in animal cells with a pair of
centrioles at their core. They template cilia during interphase and help organize the mitotic …