Podocytopathies

JB Kopp, HJ Anders, K Susztak, MA Podestà… - Nature Reviews …, 2020 - nature.com
Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

Childhood nephrotic syndrome

M Vivarelli, K Gibson, A Sinha, O Boyer - The Lancet, 2023 - thelancet.com
Idiopathic nephrotic syndrome is the most common glomerular disease in children.
Corticosteroids are the cornerstone of its treatment, and steroid response is the main …

Incidence and relapse of idiopathic nephrotic syndrome: meta-analysis

F Veltkamp, LR Rensma, AHM Bouts - Pediatrics, 2021 - publications.aap.org
Incidence and Relapse of Idiopathic Nephrotic Syndrome: Meta-analysis | Pediatrics | American
Academy of Pediatrics Skip to Main Content Disclaimer » Advertising AAP logo Search Close …

Molecular stratification of idiopathic nephrotic syndrome

MA Saleem - Nature Reviews Nephrology, 2019 - nature.com
Idiopathic nephrotic syndrome (INS) describes a group of pathologies of the renal
glomerulus that result in the classic triad of heavy proteinuria, oedema and …

Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome

A Barry, MT McNulty, X Jia, Y Gupta, H Debiec… - Nature …, 2023 - nature.com
Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood
glomerular disease. Previous genome-wide association studies (GWAS) identified a risk …

GWAS-based discoveries in IgA nephropathy, membranous nephropathy, and steroid-sensitive nephrotic syndrome

E Sanchez-Rodriguez, CT Southard… - Clinical Journal of the …, 2021 - journals.lww.com
Over the past decade, genome-wide association studies (GWAS) have emerged as a
powerful tool to understand the genetic basis of complex traits in humans. The GWAS …

An updated view of the pathogenesis of steroid-sensitive nephrotic syndrome

T Horinouchi, K Nozu, K Iijima - Pediatric Nephrology, 2022 - Springer
Idiopathic nephrotic syndrome is the most common childhood glomerular disease. Most
forms of this syndrome respond to corticosteroids at standard doses and are, therefore …

[HTML][HTML] State of the art in childhood nephrotic syndrome: concrete discoveries and unmet needs

F Vincenti, A Angeletti, GM Ghiggeri - Frontiers in Immunology, 2023 - ncbi.nlm.nih.gov
Nephrotic syndrome (NS) is a clinical entity characterized by proteinuria, hypoalbuminemia,
and peripheral edema. NS affects about 2–7 per 100,000 children aged below 18 years old …

Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome

X Jia, T Yamamura, R Gbadegesin, MT McNulty… - Kidney international, 2020 - Elsevier
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a
genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls …

Molecular mechanisms of proteinuria in minimal change disease

S Purohit, F Piani, FA Ordoñez… - Frontiers in …, 2021 - frontiersin.org
Minimal change disease (MCD) is the most common type of idiopathic nephrotic syndrome
in childhood and represents about 15% cases in adults. It is characterized by massive …