Primary Sjogren's syndrome (pSS) is a complex and heterogeneous disorder characterised
by a wide spectrum of glandular and extra-glandular features. The discovery of novel …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

In this study, we report on the synthesis of silver nanoparticles (AgNPs) from the leaf extracts
of Cynara scolymus (Artichoke) using microwave irradiation and the evaluation of its anti …

Canonically, the transcription factor interferon regulatory factor 5 (IRF5) is a key mediator of
innate and adaptive immunity downstream of pathogen recognition receptors such as Toll …

Exosomes have come to the fore in drug delivery systems due to their biological-based and
immune-suppressing properties. In this study, we investigated the effect of doxorubicin …

A new series of N-(4-(1-Phenyl-5-aryl-4, 5-dihydro-1H-pyrazol-3-yl) phenyl)-4-
substitutedbenzamide derivatives were designed and synthesized from new chalcone …

Osteosarcoma (OS) is a malignant bone tumor among adolescents and young adults. IRF7
belongs to the transcription factor family of interferon regulatory factors (IRFs) and has …

The interferon regulatory factors (IRFs) are a family of master transcription factors that
regulate pathogen-induced innate and acquired immune responses. Aberration (s) in IRF …

Metastasis is driven by extensive cooperation between a tumor and its microenvironment,
resulting in the adaptation of molecular mechanisms that evade the immune system and …

Genetic variants within or near the interferon regulatory factor 5 (IRF5) locus associate with
systemic lupus erythematosus (SLE) across ancestral groups. The major IRF5-SLE risk …