Epilepsy is one of the most common neurological disorders worldwide and it requires a long- term or life-long treatment. Current standard treatment includes the use of antiepileptic …
IH Ali, RM Hassan, AM El Kerdawy… - European Journal of …, 2024 - Elsevier
In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …
A new series of N-(2-((4-(1, 3-diphenyl-1H-pyrazol-4-yl) pyridine sulfonamide derivatives 11a-o were designed and synthesized based on our previous works. The new series was …
In the current work, a series of novel 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids (10a-o) and (11a-e) were synthesized and evaluated as new PPARα agonists in …
The new series of 5a-e, 6a-e and 7a-e derivatives were designed, synthesized and tested for their anticonvulsant activity using “gold standard methods” ScPTZ and MES model …
WH Abd-Allah, MS Abd El-Maksoud… - Medicinal Chemistry …, 2024 - Springer
Aiming to develop novel anticonvulsant agents a new series of novel cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential …
I Ali, AM El Kerdawy, RZ Batran, RM Allam… - Egyptian Journal of …, 2024 - journals.ekb.eg
In the current study, a new series of N-acetylpyrazolines (6a-d) were designed and synthesized from their corresponding chalcones and hydrazine hydrate in acidic medium …
A series of coumarin derivatives 6–8, 9a-h, 11 and 13a, b-16a, b was synthesized and screened for their anticonvulsant profile. Screening of these analogues using the'gold …
In this work a set of novel derivatives of parabanic acid 9a-d, 12a-d and 13a-d was synthesized and their anticonvulsant potential was evaluated. All the compounds under …