Recent advances in the synthesis of hydantoins: the state of the art of a valuable scaffold

L Konnert, F Lamaty, J Martinez, E Colacino - Chemical Reviews, 2017 - ACS Publications
The review highlights the hydantoin syntheses presented from the point of view of the
preparation methods. Novel synthetic routes to various hydantoin structures, the advances …

A review on the synthesis and applications of molecules as anticonvulsant drug agent candidates

O Özbek, MB Gürdere - Medicinal Chemistry Research, 2020 - Springer
Epilepsy is one of the most common neurological disorders worldwide and it requires a long-
term or life-long treatment. Current standard treatment includes the use of antiepileptic …

Novel thiazolidin-4-one benzenesulfonamide hybrids as PPARγ agonists: Design, synthesis and in vivo anti-diabetic evaluation

IH Ali, RM Hassan, AM El Kerdawy… - European Journal of …, 2024 - Elsevier
In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …

Anticancer profile and anti-inflammatory effect of new N-(2-((4-(1, 3-diphenyl-1H-pyrazol-4-yl) pyridine sulfonamide derivatives

MS Abdel-Maksoud, RM Hassan, AAS El-Azzouny… - Bioorganic …, 2021 - Elsevier
A new series of N-(2-((4-(1, 3-diphenyl-1H-pyrazol-4-yl) pyridine sulfonamide derivatives
11a-o were designed and synthesized based on our previous works. The new series was …

Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPARα agonists with anti-hyperlipidemic and antioxidant activities: Design …

RM Hassan, ME Aboutabl, M Bozzi, MF El-Behairy… - Bioorganic …, 2021 - Elsevier
In the current work, a series of novel 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate
hybrids (10a-o) and (11a-e) were synthesized and evaluated as new PPARα agonists in …

Exploring new cyclohexane carboxamides based GABA agonist: Design, synthesis, biological evaluation, in silico ADME and docking studies

WH Abd-Allah, MAEM Anwar, ER Mohammed… - Bioorganic …, 2023 - Elsevier
The new series of 5a-e, 6a-e and 7a-e derivatives were designed, synthesized and tested
for their anticonvulsant activity using “gold standard methods” ScPTZ and MES model …

Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants

WH Abd-Allah, MS Abd El-Maksoud… - Medicinal Chemistry …, 2024 - Springer
Aiming to develop novel anticonvulsant agents a new series of novel
cycloalkanecarboxamide parabanic acid hybrids series 8, 9 and 10 possessing the essential …

Discovery of Novel N-Acetylpyrazolines as Microtubule Inhibitors: Design, Synthesis, Anticancer Evaluation, and Molecular Docking Study

I Ali, AM El Kerdawy, RZ Batran, RM Allam… - Egyptian Journal of …, 2024 - journals.ekb.eg
In the current study, a new series of N-acetylpyrazolines (6a-d) were designed and
synthesized from their corresponding chalcones and hydrazine hydrate in acidic medium …

Design, synthesis and docking studies of novel benzopyrone derivatives as anticonvulsants

WH Abd-Allah, EEA Osman, MAEM Anwar, HN Attia… - Bioorganic …, 2020 - Elsevier
A series of coumarin derivatives 6–8, 9a-h, 11 and 13a, b-16a, b was synthesized and
screened for their anticonvulsant profile. Screening of these analogues using the'gold …

Design and synthesis of novel parabanic acid derivatives as anticonvulsants

ME Aboutabl, RM Hassan, AAS El-Azzouny… - Bioorganic …, 2020 - Elsevier
In this work a set of novel derivatives of parabanic acid 9a-d, 12a-d and 13a-d was
synthesized and their anticonvulsant potential was evaluated. All the compounds under …