Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

M Shang, RH Soon, CT Lim, BL Khoo, J Han - Lab on a Chip, 2019 - pubs.rsc.org
Cancer is the leading cause of death worldwide. The complex and disorganized tumor
microenvironment makes it very difficult to treat this disease. The most common in vitro drug …

Overview of current advances in extrusion bioprinting for skin applications

A Perez-Valle, C Del Amo, I Andia - International Journal of Molecular …, 2020 - mdpi.com
Bioprinting technologies, which have the ability to combine various human cell phenotypes,
signaling proteins, extracellular matrix components, and other scaffold-like biomaterials, are …

A bone‐on‐a‐chip collagen hydrogel‐based model using pre‐differentiated adipose‐derived stem cells for personalized bone tissue engineering

P Alamán‐Díez, E García‐Gareta… - … Research Part A, 2023 - Wiley Online Library
Mesenchymal stem cells have contributed to the continuous progress of tissue engineering
and regenerative medicine. Adipose‐derived stem cells (ADSC) possess many advantages …

Microfluidics and hydrogel: A powerful combination

CB Goy, RE Chaile, RE Madrid - Reactive and Functional Polymers, 2019 - Elsevier
Microfluidics is a very useful and promising technology that allowed engineering a huge
variety of developments in several fields, such as biology, biomedical engineering …

Combined experimental and computational characterization of crosslinked collagen-based hydrogels

C Valero, H Amaveda, M Mora, JM García-Aznar - PLoS One, 2018 - journals.plos.org
Collagen hydrogels are widely used for in-vitro experiments and tissue engineering
applications. Their use has been extended due to their biocompatibility with cells and their …

Primary human osteoblasts cultured in a 3D microenvironment create a unique representative model of their differentiation into osteocytes

G Nasello, P Alamán-Díez, J Schiavi… - … in bioengineering and …, 2020 - frontiersin.org
Microengineered systems provide an in vitro strategy to explore the variability of individual
patient response to tissue engineering products, since they prefer the use of primary cell …

Investigations on T cell transmigration in a human skin-on-chip (SoC) model

X Ren, AE Getschman, S Hwang, BF Volkman… - Lab on a Chip, 2021 - pubs.rsc.org
A microfluidics-based three-dimensional skin-on-chip (SoC) model is developed in this
study to enable quantitative studies of transendothelial and transepithelial migration of …

Topotactic fibrillogenesis of freeze-cast microridged collagen scaffolds for 3D cell culture

C Rieu, C Parisi, G Mosser, B Haye… - … applied materials & …, 2019 - ACS Publications
Type I collagen is the main component of the extracellular matrix (ECM). In vitro, under a
narrow window of physicochemical conditions, type I collagen self-assembles to form …

Biofabrication strategies and engineered in vitro systems for vascular mechanobiology

S Pradhan, OA Banda, CJ Farino… - Advanced …, 2020 - Wiley Online Library
The vascular system is integral for maintaining organ‐specific functions and homeostasis.
Dysregulation in vascular architecture and function can lead to various chronic or acute …

A microfluidic-based analysis of 3D macrophage migration after stimulation by Mycobacterium, Salmonella and Escherichia

S Pérez-Rodríguez, C Borau, JM García-Aznar… - BMC microbiology, 2022 - Springer
Macrophages play an essential role in the process of recognition and containment of
microbial infections. These immune cells are recruited to infectious sites to reach and …