Polysaccharide nanoparticles: From fabrication to applications

A Plucinski, Z Lyu, BVKJ Schmidt - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Polysaccharides have attracted considerable attention in a broad range of applications in
recent years, which is due to their remarkable features such as biocompatibility …

Chitosan-based nanoparticles for nucleic acid delivery: technological aspects, applications, and future perspectives

M Karayianni, T Sentoukas, A Skandalis, N Pippa… - Pharmaceutics, 2023 - mdpi.com
Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is
an abundant carbohydrate found mainly in the shells of various marine and terrestrial …

Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy

F Li, J Wu, D Li, L Hao, Y Li, D Yi, KWK Yeung… - Journal of …, 2022 - Springer
Background Exosomes derived from stem cells have been widely studied for promoting
regeneration and reconstruction of multiple tissues as “cell-free” therapies. However, the …

Recent advances in functional polymer materials for energy, water, and biomedical applications: a review

Y El-Ghoul, FM Alminderej, FM Alsubaie, R Alrasheed… - Polymers, 2021 - mdpi.com
Academic research regarding polymeric materials has been of great interest. Likewise,
polymer industries are considered as the most familiar petrochemical industries. Despite the …

[HTML][HTML] Fabrication and characterization of pcDNA3. 1 (+) location within chitosan/nanoparticles complexes for enhanced gene delivery

T Piri-Gharaghie, A Doosti… - Iranian Journal of …, 2022 - ncbi.nlm.nih.gov
Background: Chitosan nanoparticles (CSNP) are becoming a popular alternative for
delivering nucleic acids to tissues for gene transfer (gene therapy). The size and …

Delivery of CRISPR/Cas9 plasmid DNA by hyperbranched polymeric nanoparticles enables efficient gene editing

K Xiu, L Saunders, L Wen, J Ruan, R Dong, J Song… - Cells, 2022 - mdpi.com
Gene editing nucleases such as CRISPR/Cas9 have enabled efficient and precise gene
editing in vitro and hold promise of eventually achieving in vivo gene editing based therapy …

Design of experiments to achieve an efficient chitosan-based DNA vaccine delivery system

C Rodolfo, D Eusébio, C Ventura, R Nunes… - Pharmaceutics, 2021 - mdpi.com
In current times, DNA vaccines are seen as a promising approach to treat and prevent
diseases, such as virus infections and cancer. Aiming at the production of a functional and …

SMO-CRISPR-mediated apoptosis in CD133-targeted cancer stem cells and tumor growth inhibition

S Pandey, M Lee, J Lim, S Park, YH Choung… - Journal of Controlled …, 2023 - Elsevier
Cancer stem cells (CSCs) possess the ability to indefinitely proliferate and resist therapy,
leading to cancer relapse and metastasis. To address this, we aimed to develop a CSC …

Modulation of chitosan-TPP nanoparticle properties for plasmid DNA vaccines delivery

R Nunes, AS Serra, A Simaite, Â Sousa - Polymers, 2022 - mdpi.com
Nucleic acid vaccines have become a revolutionary technology to give a fast, safe, cost-
effective and efficient response against viral infections, such as SARS-CoV-2 or Human …

On the Fractionation and Physicochemical Characterisation of Self-Assembled Chitosan–DNA Polyelectrolyte Complexes

A Sajid, M Castronovo, FM Goycoolea - Polymers, 2023 - mdpi.com
Chitosan is extensively studied as a carrier for gene delivery and is an attractive non-viral
gene vector owing to its polycationic, biodegradable, and biocompatible nature. Thus, it is …