Challenges of unculturable bacteria: environmental perspectives

A Bodor, N Bounedjoum, GE Vincze… - … Science and Bio …, 2020 - Springer
Environmental biotechnology offers several promising techniques for the rehabilitation of
polluted environments. The modern industrialized world presents novel challenges to the …

Bacillus spore germination: Knowns, unknowns and what we need to learn

G Christie, P Setlow - Cellular Signalling, 2020 - Elsevier
How might a microbial cell that is entirely metabolically dormant–and which has the ability to
remain so for extended periods of time–irreversibly commit itself to resuming vegetative …

Extreme slow growth as alternative strategy to survive deep starvation in bacteria

DA Gray, G Dugar, P Gamba, H Strahl… - Nature …, 2019 - nature.com
Bacteria can become dormant or form spores when they are starved for nutrients. Here, we
find that non-sporulating Bacillus subtilis cells can survive deep starvation conditions for …

Germination of Spores of the Orders Bacillales and Clostridiales

P Setlow, S Wang, YQ Li - Annual review of microbiology, 2017 - annualreviews.org
Dormant Bacillales and Clostridiales spores begin to grow when small molecules
(germinants) trigger germination, potentially leading to food spoilage or disease …

Tracking bacterial lineages in complex and dynamic environments with applications for growth control and persistence

S Bakshi, E Leoncini, C Baker, SJ Cañas-Duarte… - Nature …, 2021 - nature.com
As bacteria transition from exponential to stationary phase, they change substantially in size,
morphology, growth and expression profiles. These responses also vary between individual …

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

DB Kell, E Pretorius - Biological Reviews, 2018 - Wiley Online Library
Since the successful conquest of many acute, communicable (infectious) diseases through
the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and …

Reaching unreachables: Obstacles and successes of microbial cultivation and their reasons

G Kapinusova, MA Lopez Marin, O Uhlik - Frontiers in Microbiology, 2023 - frontiersin.org
In terms of the number and diversity of living units, the prokaryotic empire is the most
represented form of life on Earth, and yet it is still to a significant degree shrouded in …

Persisters—as elusive as ever

N Kaldalu, V Hauryliuk, T Tenson - Applied microbiology and …, 2016 - Springer
Persisters—a drug-tolerant sub-population in an isogenic bacterial culture—have been
featured throughout the last decade due to their important role in recurrent bacterial …

Quorum sensing controls persistence, resuscitation, and virulence of Legionella subpopulations in biofilms

N Personnic, B Striednig, H Hilbi - The ISME journal, 2021 - academic.oup.com
The water-borne bacterium Legionella pneumophila is the causative agent of Legionnaires'
disease. In the environment, the opportunistic pathogen colonizes different niches, including …

Bacillus spore germination: mechanisms, identification, and antibacterial strategies

L Fan, Y Zhang, BB Ismail, AI Muhammad… - Critical reviews in food …, 2024 - Taylor & Francis
Bacterial spores are metabolically inactive and highly resistant to harsh environmental
conditions in nature and during decontamination processes in food and related industries …