In recent years, there has been a significant demand for natural products as a mean of
disease prevention or as an alternative to conventional medications. The driving force for …

Gliomas are incurable brain cancers with poor prognosis, with epigenetic dysregulation
being a distinctive feature. 5-hydroxymethylcytosine (5-hmC), an intermediate generated in …

Background A variety of dietary adjuncts are known to affect the pathophysiology of glioma,
making them a potential therapeutic adjunct to standard of care. We systematically reviewed …

Recently, the FDA-approved iron oxide nanoparticle, ferumoxytol, has been found to
enhance the efficacy of pharmacological ascorbate (AscH−) in treating glioblastoma, as …

Gliomas are the most common primary brain cancer diagnosed in adults. Gliomas arise from
glial cells within the central nervous system, and vary in severity based on a World Health …

Vitamin C is an essential micronutrient that is involved in many biological processes in the
body. Ascorbate, the most common form of vitamin C found in physiological pH is widely …

Glioblastoma multiforme (GBM) is incurable with routine treatments. Ascorbic acid (Asc) has
antioxidant and anti-cancer properties. However, its specific anti-cancer mechanisms are …