Decades of successful use of antibiotics is currently challenged by the emergence of
increasingly resistant bacterial strains. Novel drugs are urgently required but, in a scenario …

Antimicrobials against bacterial, viral and parasitic pathogens have transformed human and
animal health. Nevertheless, their widespread use (and misuse) has led to the emergence of …

Available genomic data for pathogens has created new opportunities for drug discovery and
development to fight them, including new resistant and multiresistant strains. In particular …

Mycobacterium tuberculosis (Mtb) strains of Beijing lineage have caused great concern
because of their rapid emergence of drug resistance and worldwide spread. DNA mutation …

Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can
cause life-threatening infections. It has been found as the culprit of many infection outbreaks …

Phenotypic screening is a powerful technique that allowed the discovery of antimicrobials to
fight infectious diseases considered deadly less than a century ago. In high throughput …

A comparative genome analysis of the global anaerobic regulator Anr regulon in five
species of Pseudomonas with different life style was performed. Expression of this regulator …

Listeria monocytogenes (Lm) is a Gram-positive bacillus responsible for listeriosis in
humans. Listeriosis has become a major foodborne illness in recent years. This illness is …

While Tuberculosis (TB) infection remains a serious challenge worldwide, big data and
“omic” approaches have greatly contributed to the understanding of the disease …

Tuberculosis is one of the deadliest infectious diseases worldwide and the prevalence of
latent tuberculosis acts as a huge roadblock in the global effort to eradicate tuberculosis …