With the rapid increase in the population of obese individuals, obesity has become a global
problem. Many kinds of chronic metabolic diseases easily caused by obesity have received …

It is now plausible to dock libraries of 10 million molecules against targets over several days
or weeks. When the molecules screened are commercially available, they may be rapidly …

The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous
cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols …

A thermostable T1 lipase from Geobacillus zalihae exhibits broad substrate specificity and
good potential application in fats and oils. However, structural insight into the enzyme …

Neurological and neurodegenerative diseases are debilitating conditions, and frequently
lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the …

Abstract Background The Ebola virus is highly pathogenic and destructive to humans and
other primates. The Ebola virus encodes viral protein 40 (VP40), which is highly expressed …

Cyclin-dependent kinases are of critical importance in directing various cell cycle phases
making them as potential tumor targets. Cyclin-dependent kinase 2 (CDK2) in particular …

Computational screening is a method to prioritize small-molecule compounds based on the
structural and biochemical attributes built from ligand and target information. Previously, we …

Marburg virus infections are extremely fatal with a fatality range of 23% to 90%, therefore
there is an urgent requirement to design and develop efficient therapeutic molecules. Here …

Monoacylglycerol lipase (MAGL) is a 33 kDa serine protease primarily responsible for
hydrolyzing 2-arachidonoylglycerol into the proinflammatory eicosanoid precursor …