While it has often been assumed that, in humans, synonymous mutations would have no effect on fitness, let alone cause disease, this position has been questioned over the last …
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust …
Z Yang, R Nielsen - Molecular biology and evolution, 2008 - academic.oup.com
Current models of codon substitution are formulated at the levels of nucleotide substitution and do not explicitly consider the separate effects of mutation and selection. They are thus …
Non-coding DNA comprises∼ 80% of the euchromatic portion of the Drosophila melanogaster genome. Non-coding sequences are known to contain functionally important …
DJ Begun, P Whitley, BL Todd, HM Waldrip-Dail… - Genetics, 2000 - academic.oup.com
Drosophila seminal proteins have an unusually high rate of molecular sequence evolution, suggesting either a high rate of neutral substitution or rapid adaptive evolution. To further …
GAT McVEAN, B Charlesworth - Genetics Research, 1999 - cambridge.org
Patterns of synonymous codon usage are determined by the forces of mutation, selection and drift. We elaborate on previous population genetic models of codon usage to …
Selection acting on codon usage can cause patterns of synonymous evolution to deviate considerably from those expected under neutrality. To investigate the quantitative …
Despite the degeneracy of the genetic code, whereby different codons encode the same amino acid, alternative codons and amino acids are utilized nonrandomly within and …
AD Cutter, R Jovelin, A Dey - Molecular ecology, 2013 - Wiley Online Library
The genomic density of sequence polymorphisms critically affects the sensitivity of inferences about ongoing sequence evolution, function and demographic history. Most …