Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

Cultivated meat production requires an efficient, robust and highly optimized serum-free cell
culture media for the needed upscaling of muscle cell expansion. Existing formulations of …

Nuclear pore complexes (NPCs) have emerged as genome organizers, defining a particular
nuclear compartment enriched for SUMO protease and proteasome activities, and act as …

Abstract Exportin-1 (XPO1), the main soluble nuclear export receptor in eukaryotic cells, is
frequently overexpressed in diffuse large B-cell lymphoma (DLBCL). A selective XPO1 …

Ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) DNA
damage response (DDR) kinases contain elastic domains. ATM also responds to reactive …

DNA lesions in S phase threaten genome stability. The DNA damage tolerance (DDT)
pathways overcome these obstacles and allow completion of DNA synthesis by the use of …

Background Temozolomide (TMZ) treatment efficacy in glioblastoma (GBM) patients has
been limited by resistance in the clinic. Currently, there are no clinically proven therapeutic …

The nuclear pore complexes (NPCs), one of the hallmarks of eukaryotic nuclei, allow
selective transport of macromolecules between the cytoplasm and the nucleus. Besides this …

Drug repurposing is a versatile strategy to improve current therapies. Disulfiram has long
been used in the treatment of alcohol dependency and multiple clinical trials to evaluate its …