Simple Summary Triple negative breast cancer, a subtype of breast cancer that does not
respond to hormone therapy, is typically more aggressive and affects younger patients …

RNA therapeutics has advanced into the third milestone in pharmaceutical drug
development, following chemical and protein therapeutics. RNA itself can serve as …

In this post hoc analysis of the ASCENT study, we compared outcomes with sacituzumab
govitecan (SG) vs single-agent chemotherapy in clinically important subgroups of patients …

A three-dimensional (3D) scaffold ideally provides hierarchical complexity and imitates the
chemistry and mechanical properties of the natural cell environment. Here, we report on a …

In situ forming implants (ISFIs) have shown promise as a sustained, local drug delivery
system for therapeutics in a variety of applications. However, development of ISFIs has been …

If cancer is hard to be treated, brain cancer is even more, caused by the inability of many
effective drugs given systemically to cross the blood brain and blood tumor barriers and …

The objective of this work was to develop self-forming doxorubicin-loaded polymeric depots
as an injectable drug delivery system for liver cancer chemotherapy and studied the release …

Purpose SN-38, a potent chemotherapeutic drug, has not been used clinically because of its
severe side effects and poor solubility. In this work, we aimed to evaluate the effect of dose …

Purpose Improved survival rates have been observed in castration‐resistant prostate cancer
(CRPC) due to advancements in treatment options. However, individuals with brain …

Lipid and micelle-based nanocarriers have been explored for anticancer drug delivery to
improve accumulation and uptake in tumor tissue. As an experimental opportunity in this …