Combining excellent selectivity with broad target scope: biosensing with arrayed deep cavitand hosts

W Zhong, RJ Hooley - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Simple macrocyclic water-soluble hosts such as cucurbiturils, cyclophanes, and
calixarenes have long been used for biosensing via indicator displacement assays. Using …

Using photo-initiated polymerization reactions to detect molecular recognition

K Kaastrup, HD Sikes - Chemical Society Reviews, 2016 - pubs.rsc.org
Widely used medical diagnostic devices and assays that sense the presence of a particular
molecule in a bodily fluid often rely on either a nanoparticle label or an enzymatic reaction to …

Responsive inverse opal hydrogels for the sensing of macromolecules

JP Couturier, M Sütterlin, A Laschewsky… - Angewandte Chemie …, 2015 - Wiley Online Library
Dual responsive inverse opal hydrogels were designed as autonomous sensor systems for
(bio) macromolecules, exploiting the analyte‐induced modulation of the opal's structural …

“Two-in-one” core–shell nanozyme probes with double signal amplification for high-performing surface plasmon resonance immunosensing

F Shi, F Yan, X Zhang, R Liu, G Jiang, J Li… - Chemical …, 2023 - pubs.rsc.org
Herein, a “two-in-one” Ag@ Au core–shell nanozyme probe inducing double-signal
amplification has been developed to significantly elevate the sensitivity of SPR sensors via …

HRP-mimicking DNAzyme-catalyzed in situ generation of polyaniline to assist signal amplification for ultrasensitive surface plasmon resonance biosensing

H Li, J Chang, T Hou, F Li - Analytical chemistry, 2017 - ACS Publications
It is well-known that the horseradish peroxidase-(HRP-) mimicking DNAzyme, namely,
hemin/G-quadruplex, can effectively catalyze the polymerization of aniline to form DNA …

Selective heavy element sensing with a simple host–guest fluorescent array

Y Liu, M Mettry, AD Gill, L Perez, W Zhong… - Analytical …, 2017 - ACS Publications
A simple three component array of host–fluorophore complexes is capable of sensitive and
selective discrimination of heavy metal ions, including lanthanide and actinide salts in …

[HTML][HTML] Gold nanoparticle-coupled liposomes for enhanced plasmonic biosensing

Z Yang, AS Malinick, T Yang, W Cheng… - Sensors and actuators …, 2020 - Elsevier
We report the fabrication of stable nanoclusters by salt-induced coupling of nanoparticles
onto functionalized liposomes and their application in enhanced biosensing on a biomimetic …

Selective cavitand-mediated endocytosis of targeted imaging agents into live cells

YJ Ghang, MP Schramm, F Zhang… - Journal of the …, 2013 - ACS Publications
A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis
of a specifically tagged target molecule in different types of living human cells. The presence …

Unusual orientation and reactivity of alkyl halides in water-soluble cavitands

RJ Hooley, JV Gavette, M Mettry, D Ajami… - Chemical Science, 2014 - pubs.rsc.org
Water-soluble deep cavitands with ionic peripheral groups take up hydrophobic guest
compounds in D2O. Longer n-halides and α, ω-dihalides C7–C11, are bound and NMR is …

Thermoresponsive arrays patterned via photoclick chemistry: smart MALDI plate for protein digest enrichment, desalting, and direct MS analysis

X Meng, J Hu, Z Chao, Y Liu, H Ju… - ACS applied materials & …, 2018 - ACS Publications
Sample desalting and concentration are crucial steps before matrix-assisted laser
desorption/ionization-mass spectrometry (MALDI-MS) analysis. Current sample pretreatment …