The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different
mechanisms could contribute to hyperandrogenism and anovulation, which are the main …

Multiple factors are involved in the etiology of cardiovascular disease (CVD). Pathological
changes occur in a variety of cell types long before symptoms become apparent and …

Patients with Chronic Inflammatory Rheumatic diseases (CIRD) are at increased risk of
cardiovascular disease (CVD), ascribed not only to classical risk factors, but also to the …

In the United States alone, 400 000 Americans die annu-ally of coronary artery disease, and
1 000 000 suffer acute coronary events, ie, myocardial infarction and sudden cardiac death …

Despite marked advances in medical research over the past several decades,
cardiovascular disease continues to be the primary cause of morbidity and mortality …

Objective—Interferon γ (IFN-γ) is centrally involved in atherosclerosis-related inflammation,
but its activity cannot be reliably assessed by systemic measurements. In activated …

Neopterin is produced by human and primate monocyte/macrophages upon activation by
pro-inflammatory stimuli like Th1-type cytokine interferon-γ. Neopterin has pro-oxidative …

Background Immune system activation is involved in atherosclerosis. Neopterin production
and tryptophan catabolism through the kynurenine pathway, measured by the kynurenine …

This review of literature and our data suggests that up-regulated production of interferon-
gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)–kynurenine …

Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are
mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven …