Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Modern methods of diagnostics and treatment of neurodegenerative diseases and depression

N Shusharina, D Yukhnenko, S Botman, V Sapunov… - Diagnostics, 2023 - mdpi.com
This paper discusses the promising areas of research into machine learning applications for
the prevention and correction of neurodegenerative and depressive disorders. These two …

Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial

CR Oehrn, S Cernera, LH Hammer, M Shcherbakova… - Nature Medicine, 2024 - nature.com
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …

A systematic review of local field potential physiomarkers in Parkinson's disease: from clinical correlations to adaptive deep brain stimulation algorithms

BCM van Wijk, RMA de Bie, M Beudel - Journal of neurology, 2023 - Springer
Deep brain stimulation (DBS) treatment has proven effective in suppressing symptoms of
rigidity, bradykinesia, and tremor in Parkinson's disease. Still, patients may suffer from …

[HTML][HTML] Personalized chronic adaptive deep brain stimulation outperforms conventional stimulation in Parkinson's disease

CR Oehrn, S Cernera, LH Hammer, M Shcherbakova… - medRxiv, 2023 - ncbi.nlm.nih.gov
Deep brain stimulation is a widely used therapy for Parkinson's disease (PD) but currently
lacks dynamic responsiveness to changing clinical and neural states. Feedback control has …

Neurotechnology for pain

LE Fisher, SF Lempka - Annual Review of Biomedical …, 2023 - annualreviews.org
Neurotechnologies for treating pain rely on electrical stimulation of the central or peripheral
nervous system to disrupt or block pain signaling and have been commercialized to treat a …

Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders

D Chen, Z Zhao, J Shi, S Li, X Xu, Z Wu, Y Tang… - Translational …, 2024 - nature.com
Substance use disorders (SUDs) imposes profound physical, psychological, and
socioeconomic burdens on individuals, families, communities, and society as a whole, but …

Oscillatory beta dynamics inform biomarker-driven treatment optimization for Parkinson's disease

EM Radcliffe, AJ Baumgartner… - Journal of …, 2023 - journals.physiology.org
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons and dysregulation of the basal ganglia. Cardinal motor symptoms …

Unraveling the complexities of programming neural adaptive deep brain stimulation in Parkinson's disease

KB Wilkins, JA Melbourne, P Akella… - Frontiers in Human …, 2023 - frontiersin.org
Over the past three decades, deep brain stimulation (DBS) for Parkinson's disease (PD) has
been applied in a continuous open loop fashion, unresponsive to changes in a given …

[HTML][HTML] Diving into the subcortex: The potential of chronic subcortical sensing for unravelling basal ganglia function and optimization of deep brain stimulation

BEKS Swinnen, AW Buijink, D Piña-Fuentes… - Neuroimage, 2022 - Elsevier
Subcortical structures are a relative neurophysiological 'terra incognita'owing to their
location within the skull. While perioperative subcortical sensing has been performed for …