An investigation of the impact of precipitation temperature and filter cake thickness on the physical stability of amorphous solids: A case study
Z Li, X Liao, Z Gong, B Zhang, A Nawaz - Molecules, 2024 - mdpi.com
The purpose of this study was to resolve the issue of physical instability in amorphous solid
drugs, which can result in unwanted crystallization, affecting solubility and dissolution rates …
drugs, which can result in unwanted crystallization, affecting solubility and dissolution rates …
6-Carboxycellulose Acetate Butyrate: Effectiveness as an Amorphous Solid Dispersion Polymer
JA Marks, BLB Nichols… - Molecular …, 2024 - ACS Publications
Amorphous solid dispersion (ASD) in a polymer matrix is a powerful method for enhancing
the solubility and bioavailability of otherwise crystalline, poorly water-soluble drugs. 6 …
the solubility and bioavailability of otherwise crystalline, poorly water-soluble drugs. 6 …
Effects of hypromellose acetate succinate on recrystallization inhibition, miscibility, and dissolution enhancement of baloxavir marboxil solid dispersions
L Wang, H Wu, Z Wang, Z Ding, Y Zhao, S Li… - International Journal of …, 2024 - Elsevier
Solid dispersions (SDs) have emerged as a promising strategy to enhance the solubility and
bioavailability of poorly soluble active pharmaceutical ingredients. However, SDs tend to …
bioavailability of poorly soluble active pharmaceutical ingredients. However, SDs tend to …
[HTML][HTML] Trends in amorphous solid dispersion drug products approved by the US Food and Drug Administration between 2012 and 2023
Abstract Forty-eight (48) drug products (DPs) containing amorphous solid dispersions
(ASDs) have been approved by the US Food and Drug Administration in the 12-year period …
(ASDs) have been approved by the US Food and Drug Administration in the 12-year period …
[HTML][HTML] Utilizing the allyl-terminated copolymer methoxy (poly (ethylene glycol))-block-poly (jasmine lactone) in the development of amorphous solid dispersions: A …
Molecular interactions are crucial to stabilize amorphous drugs in amorphous solid
dispersions (ASDs). Most polymers, however, have only a limited ability to form strong …
dispersions (ASDs). Most polymers, however, have only a limited ability to form strong …
Exploring biorelevant conditions and release profiles of ritonavir from HPMCAS-based amorphous solid dispersions
Abstract Development of a release test for amorphous solid dispersions (ASDs) that is in
vivo predictive is essential to identify optimally performing formulations early in …
vivo predictive is essential to identify optimally performing formulations early in …
The importance of surface composition and wettability on the dissolution performance of high drug loading amorphous dispersion formulations
TN Hiew, MA Solomos, P Kafle, H Polyzois… - Journal of …, 2024 - Elsevier
One of the limitations with an amorphous solid dispersion (ASD) formulation strategy is low
drug loading. Hydrophobic drugs have poor wettability and require a substantial amount of …
drug loading. Hydrophobic drugs have poor wettability and require a substantial amount of …