The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …

The control of stem cell response in vitro, including self‐renewal and lineage commitment,
has been proved to be directed by mechanical cues, even in the absence of biochemical …

Organized cellular alignment is critical to controlling tissue microarchitecture and biological
function. Although a multitude of techniques have been described to control cellular …

Regulated biophysical cues, such as nanotopography, have been shown to be integral for
tissue regeneration and embryogenesis in the stem cell niche. Tissue homeostasis involves …

Material engineering methods have been used for many years to develop biomedical
devices for use within the body to augment, repair or replace damaged tissues ranging from …

Mechanical interactions of mesenchymal stem cells (MSC) with the environment play a
significant role in controlling the diverse biological functions of these cells. Mechanical …

Stem cell differentiation can be regulated by biophysical cues such as nanotopography. It
involves sensing and integration of these biophysical cues into their transcriptome with a …

The interplay of biophysical and biochemical cues in the extracellular microenvironment
regulate and control the cell fate of stem cells. Understanding the interaction between stem …

Poly (ether ether ketone)(PEEK) has emerged as a candidate to replace metal implants
because of its satisfactory mechanical properties, radiolucency, and lack of metal allergy …

Aim: Topographically modified substrates are increasingly used in tissue engineering to
enhance biomimicry. The overarching hypothesis is that topographical cues will control …