Cannabinoid receptor 1 ligands: Biased signaling mechanisms driving functionally selective drug discovery
L Tian, T Qiang, S Liu, B Zhang, Y Zhang… - Pharmacology & …, 2025 - Elsevier
G protein-coupled receptors (GPCRs) adopt conformational states that activate or inhibit
distinct signaling pathways, including those mediated by G proteins or β-arrestins. Biased …
distinct signaling pathways, including those mediated by G proteins or β-arrestins. Biased …
Bridging the gap: The endocannabinoid system as a functional fulcrum for benzodiazepines in a novel frontier of anxiety pharmacotherapy
S Pakkhesal, M Shakouri, R Mosaddeghi-Heris… - Pharmacology & …, 2025 - Elsevier
While benzodiazepines have been a mainstay of the pharmacotherapy of anxiety disorders,
their short-term efficacy and risk of abuse have driven the exploration of alternative treatment …
their short-term efficacy and risk of abuse have driven the exploration of alternative treatment …
Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence
X Navarri, DN Robertson, I Charfi… - Journal of …, 2024 - jneurosci.org
During adolescence, cannabis experimentation is common, and its association with
interindividual variations in brain maturation well studied. Cellular and molecular …
interindividual variations in brain maturation well studied. Cellular and molecular …
No Evidence for Endocannabinoid-Induced G Protein Subtype Selectivity at Human and Rodent Cannabinoid CB1 Receptors
Introduction: The endocannabinoid system (ECS) is a widespread neurotransmitter system.
A key characteristic of the ECS is that there are multiple endogenous ligands …
A key characteristic of the ECS is that there are multiple endogenous ligands …
Synthesis and functional evaluation of proteinogenic amino acid-derived synthetic cannabinoid receptor agonists related to MPP-5F-PICA, MMB-5F-PICA, and MDMB …
Synthetic cannabinoid receptor agonists (SCRAs) comprise the second largest class of new
psychoactive substances (NPS), and typically α-amino acid moieties are incorporated as …
psychoactive substances (NPS), and typically α-amino acid moieties are incorporated as …
Determination of ADB-BUTINACA in rat plasma by UPLC-MS/MS and its application
Y Du, S Ma, D Chen, R Wang, X Wang… - Acta …, 2024 - akjournals.com
A fast, accurate, sturdy, and sensitive UPLC-MS/MS method was developed to measure the
levels of ADB-BUTINACA in rat plasma for a pharmacokinetic study. The ADB-BUTINACA …
levels of ADB-BUTINACA in rat plasma for a pharmacokinetic study. The ADB-BUTINACA …
MODULATION OF CB1 AND CB2 RECEPTORS AND ENDOCANNABINOID ACTIVITY IN INFLAMMATORY BOWEL DISEASES.
M Wolyniak, M Wlodarczyk, F Piscitelli… - … of Physiology & …, 2024 - search.ebscohost.com
The endocannabinoid system (ECS) and nociceptin receptor (NOP) have been implicated in
the pathology of inflammatory bowel diseases (IBD) mediating pain and alleviating …
the pathology of inflammatory bowel diseases (IBD) mediating pain and alleviating …
[HTML][HTML] Cannabielsoin (CBE), a CBD Oxidation Product, Is a Biased CB1 Agonist
M Haghdoost, S Young, M Roberts, C Krebs… - Biomedicines, 2024 - mdpi.com
Cannabielsoin (CBE) is primarily recognized as an oxidation byproduct of cannabidiol
(CBD) and a minor mammalian metabolite of CBD. The pharmacological interactions …
(CBD) and a minor mammalian metabolite of CBD. The pharmacological interactions …
Assessment of high-efficacy agonism in synthetic cannabinoid receptor agonists containing l-tert-leucinate
C Lucaj, C Pitha, J Davis, H Yano - bioRxiv, 2024 - biorxiv.org
Synthetic cannabinoid receptor agonists (SCRAs) represent a class of new psychoactive
substances that pose great health risks attributed to their wide-ranging and severe adverse …
substances that pose great health risks attributed to their wide-ranging and severe adverse …