Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …

The early stages of life are associated with increased susceptibility to infection, which is in
part due to an ineffective immune system. In the context of infection, the immune system …

The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …

CD8+ T cells are classically recognized as adaptive lymphocytes based on their ability to
recognize specific foreign antigens and mount memory responses. However, recent studies …

The developing human fetus generates both tolerogenic and protective immune responses
in response to the unique requirements of gestation. Thus, a successful human pregnancy …

Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

Neonatal CD4+ and CD8+ T cells have historically been characterized as immature or
defective. However, recent studies prompt a reinterpretation of the functions of neonatal T …

Background Breastfeeding is associated with long‐term health benefits, such as a lower
incidence of childhood infections, asthma, obesity and autoimmune disorders. However …

Respiratory infectious diseases encountered early in life may result in life-threatening
disease in neonates, which is primarily explained by the relatively naive neonatal immune …

Immune diversification helps protect the host against a myriad of pathogens. CD8+ T cells
are essential adaptive immune cells that inhibit the spread of pathogens by inducing …