The decline in human reproductive and metabolic health over the past 50 years is
associated with exposure to complex mixtures of anthropogenic environmental chemicals …

Male fertility has been deteriorating worldwide for considerable time, with the greatest
deterioration recorded mainly in the United States, Europe countries, and Australia. That is …

Background: It has been estimated that a substantial portion of chronic and
noncommunicable diseases can be caused or exacerbated by exposure to environmental …

Genomic imprinting is an epigenetic mechanism that results in monoallelic, parent-of-origin-
specific expression of a small number of genes. Imprinted genes play a crucial role in …

Similar to other vertebrates, androgens regulate spermatogenesis in fishes. In teleosts, the
main androgen is 11-Ketotestosterone (11-KT), which is oxidized testosterone (T) at the C …

The pharmacoepigenetic apparatus is integrated by gene clusters of different categories,
including (i) pathogenic genes involved in disease pathogenesis,(ii) mechanistic genes …

Deficiency of methyl donor nutrients folate, choline, and methionine (methyl deficiency)
during gestation can impair fetal development and perturb DNA methylation. Here, we …

Exposure to environmental chemicals has been proven to drive epigenetic changes in male
and female germ cells. We here review those experimental and human studies that …

Endocrine disruptors (EDs) are chemical substances that affect physiological processes in
the body via hormonal regulation. They are often detected in food, plastic water bottles …

Epigenetic transgenerational inheritance represents the germ line transmission of
epigenetic information, known as sperm or ovary epimutations, between generations without …