The cre‐loxP–mediated recombination system (the “cre‐loxP system”) is an integral
experimental tool for mammalian genetics and cell biology. Use of the system has greatly …

Site-specific recombinase systems (Cre-loxP, Flp-FRT, and φC31-att) are transforming both
forward and reverse genetics in mice. By enabling high-fidelity DNA modifications to be …

INTRODUCTION Resident tissue macrophages (RTMs) are a heterogeneous population of
immune cells occupying multiple tissue niches and exhibiting microenvironment-specific …

T cells that recognize tumor antigens are crucial for mounting antitumor immune responses.
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …

Selenoproteins are rare proteins among all kingdoms of life containing the 21 st amino acid,
selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of …

The bone marrow contains peripheral nerves that promote haematopoietic regeneration
after irradiation or chemotherapy (myeloablation), but little is known about how this is …

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under
transplantation conditions,. It has been particularly challenging to study dynamic HSC …

Haematopoietic stem cells (HSCs) reside in a perivascular niche but the specific location of
this niche remains controversial. HSCs are rare and few can be found in thin tissue sections …

Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin
into chromatin loops, and topologically associated domains,,,, which have important roles in …

NAD+ is an important cofactor regulating metabolic homeostasis and a rate-limiting
substrate for sirtuin deacylases. We show that NAD+ levels are reduced in aged mice and …