The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Importance Hepatitis C virus (HCV) infects more than 185 million individuals worldwide.
Twenty percent of patients chronically infected with HCV progress to cirrhosis. New, simpler …

Context New trial data and drug regimens that have become available in the last 2 years
warrant an update to guidelines for antiretroviral therapy (ART) in human immunodeficiency …

Background The combination of daclatasvir, a hepatitis C virus (HCV) NS5A inhibitor, and
the NS5B inhibitor sofosbuvir has shown efficacy in patients with HCV monoinfection. Data …

The HMG-CoA reductase inhibitors are a class of drugs also known as statins. These drugs
are effective and widely prescribed for the treatment of hypercholesterolemia and prevention …

Objectives Clinical trials of all‐oral direct‐acting antivirals (DAA s) for chronic hepatitis C
virus (HCV) infection reported high response rates in HCV/HIV coinfection, similar to those …

Objective: Review pharmacokinetics of new direct-acting antivirals (DAAs) for hepatitis C
(HCV) infection and interactions with concomitant immunosuppressant and antiretroviral …

Recent data have clearly shown that a sustained virologic response can be achieved in
different HCV infected patient populations with various interferon-free treatment regimens …

Background Approximately one-third of all HIV-infected individuals are coinfected with HCV,
many of whom will receive concomitant treatment for both infections. With the advent of …

Studies of boceprevir and telaprevir based antiviral therapy in liver transplant (LT) recipients
with hepatitis C genotype 1 infection have demonstrated dramatic increases in tacrolimus …