A novel diabetes typology: towards precision diabetology from pathogenesis to treatment

C Herder, M Roden - Diabetologia, 2022 - Springer
The current classification of diabetes, based on hyperglycaemia, islet-directed antibodies
and some insufficiently defined clinical features, does not reflect differences in aetiological …

Phenotypic and genetic classification of diabetes

AJ Deutsch, E Ahlqvist, MS Udler - Diabetologia, 2022 - Springer
The historical subclassification of diabetes into predominantly types 1 and 2 is well
appreciated to inadequately capture the heterogeneity seen in patient presentations …

Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes

D Mansour Aly, OP Dwivedi, RB Prasad… - Nature …, 2021 - nature.com
Type 2 diabetes has been reproducibly clustered into five subtypes with different disease
progression and risk of complications; however, etiological differences are unknown. We …

Precision subclassification of type 2 diabetes: a systematic review

S Misra, R Wagner, B Ozkan, M Schön… - Communications …, 2023 - nature.com
Background Heterogeneity in type 2 diabetes presentation and progression suggests that
precision medicine interventions could improve clinical outcomes. We undertook a …

100 YEARS OF INSULIN: Towards improved precision and a new classification of diabetes mellitus

E Ahlqvist, RB Prasad, L Groop - Journal of Endocrinology, 2022 - joe.bioscientifica.com
Type 2 diabetes (T2D) is one of the fastest increasing diseases worldwide. Although it is
defined by a single metabolite, glucose, it is increasingly recognized as a highly …

Precision medicine for cardiometabolic disease: a framework for clinical translation

PW Franks, WT Cefalu, J Dennis, JC Florez… - The Lancet Diabetes & …, 2023 - thelancet.com
Cardiometabolic disease is a major threat to global health. Precision medicine has great
potential to help to reduce the burden of this common and complex disease cluster, and to …

[HTML][HTML] Novel strategies for glycaemic control and preventing diabetic complications applying the clustering-based classification of adult-onset diabetes mellitus: A …

H Tanabe, H Masuzaki, M Shimabukuro - Diabetes Research and Clinical …, 2021 - Elsevier
Diabetes mellitus results from an interplay between insulin resistance and β-cell dysfunction.
Since their relative contributions to its pathogenesis are difficult to quantify, therapeutic …

Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population

SB Zaghlool, A Halama, N Stephan… - Nature …, 2022 - nature.com
Abstract Type 2 diabetes (T2D) has a heterogeneous etiology influencing its progression,
treatment, and complications. A data driven cluster analysis in European individuals with …

Antidiabetic plants for the treatment of type 2 diabetes mellitus and associated bacterial infections

MA Tienda-Vázquez, EM Melchor-Martínez… - Processes, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is the metabolic disease with the highest morbidity rates
worldwide. The condition is characterized by hyperglycemia, insulin resistance …

Diabetes-related excess mortality in Mexico: a comparative analysis of national death registries between 2017–2019 and 2020

OY Bello-Chavolla, NE Antonio-Villa… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE To estimate diabetes-related mortality in Mexico in 2020 compared with 2017–
2019 after the onset of the coronavirus disease 2019 (COVID-19) pandemic. RESEARCH …