Targeting AKT/mTOR in oral cancer: mechanisms and advances in clinical trials

C Harsha, K Banik, HL Ang, S Girisa… - International journal of …, 2020 - mdpi.com
Oral cancer (OC) is a devastating disease that takes the lives of lots of people globally every
year. The current spectrum of treatment modalities does not meet the needs of the patients …

Targeting the JAK/STAT signaling pathway using phytocompounds for cancer prevention and therapy

S Bose, S Banerjee, A Mondal, U Chakraborty… - Cells, 2020 - mdpi.com
Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway …

Celastrol: progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology

W Hou, B Liu, H Xu - European journal of medicinal chemistry, 2020 - Elsevier
Celastrol, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has gained
extensive exploration due to its unique structure features and multiple promising biological …

Molecular regulation of autophagy and suppression of protein kinases by aescin, a triterpenoid saponin impedes lung cancer progression

J Singh, Y Hussain, A Meena, S Luqman… - International Journal of …, 2023 - Elsevier
Lung cancer is the most common and lethal cancer worldwide, yet there are no adequate
and novel medications to control this illness. Previous reports suggested the potential of …

The vital role of ATP citrate lyase in chronic diseases

AD Khwairakpam, K Banik, S Girisa… - Journal of Molecular …, 2020 - Springer
Chronic or non-communicable diseases are the leading cause of death worldwide; they
usually result in long-term illnesses and demand long-term care. Despite advances in …

[HTML][HTML] Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis

M Qiu, K Huang, Y Liu, Y Yang, H Tang, X Liu… - Mucosal …, 2019 - Elsevier
High-fat diet (HFD) promotes lung pre-metastatic niche formation and metastasis. Thus,
there is an urgent need to identify the underlying mechanisms and develop strategies to …

Phytochemicals for the prevention and treatment of renal cell carcinoma: preclinical and clinical evidence and molecular mechanisms

EM Bajalia, FB Azzouz, DA Chism, DM Giansiracusa… - Cancers, 2022 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most frequently diagnosed kidney
cancer. Once RCC metastasizes, successful treatment is difficult to achieve. There is an …

The natural product β-escin targets cancer and stromal cells of the tumor microenvironment to inhibit ovarian cancer metastasis

HA Kenny, PC Hart, K Kordylewicz, M Lal, M Shen… - Cancers, 2021 - mdpi.com
Simple Summary β-escin, a component of horse chestnut seed extract, was first identified as
an inhibitor of ovarian cancer (OvCa) adhesion/invasion in our high-throughput screening …

β-Escin overcomes trastuzumab resistance in HER2-positive breast cancer by targeting cancer stem-like features

S Park, JM Park, M Park, D Ko, S Kim, J Seo… - Cancer Cell …, 2022 - Springer
Background The emergence of de novo or intrinsic trastuzumab resistance is exceedingly
high in breast cancer that is HER2 positive and correlates with an abundant cancer stem cell …

The Southern European atlantic diet and its supplements: The chemical bases of its anticancer properties

PG Vivanco, P Taboada, A Coelho - Nutrients, 2023 - mdpi.com
Scientific evidence increasingly supports the strong link between diet and health,
acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases …