[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
Biomarkers of aging for the identification and evaluation of longevity interventions
With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
longevity interventions in humans have become key goals of this field. Biomarkers of aging …
Determining a multimodal aging clock in a cohort of Chinese women
Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …
to address the unmet needs of the global aging population. However, to successfully do so …
Cellular senescence in skeletal disease: mechanisms and treatment
X He, W Hu, Y Zhang, M Chen, Y Ding, H Yang… - Cellular & Molecular …, 2023 - Springer
The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …
production while acting as an endocrine organ. With aging, the balance of bone …
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …
limiting the development of strategies to ameliorate age-related pathologies by preventing …
Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice
Aims The mechanisms underlying ageing-induced vascular remodelling remain unclear.
This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase …
This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase …
CRL2APPBP2-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence
Cullin-RING E3 ubiquitin ligases (CRLs), the largest family of multi-subunit E3 ubiquitin
ligases in eukaryotic cells, represent core cellular machinery for executing protein …
ligases in eukaryotic cells, represent core cellular machinery for executing protein …
Fibroblast-derived CXCL14 aggravates crystalline silica–induced pulmonary fibrosis by mediating polarization and recruitment of interstitial macrophages
Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …
Emerging epigenetic insights into aging mechanisms and interventions
Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …
still an evolving field with much to explore, it has rapidly gained significance by providing …