Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Prebiotic systems chemistry: new perspectives for the origins of life
The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …
important scientific, epistemological and social implications. Over time, philosophers and …
A scored human protein–protein interaction network to catalyze genomic interpretation
Genome-scale human protein–protein interaction networks are critical to understanding cell
biology and interpreting genomic data, but challenging to produce experimentally. Through …
biology and interpreting genomic data, but challenging to produce experimentally. Through …
Predicting protein–protein interactions from the molecular to the proteome level
Identification of protein–protein interactions (PPIs) is at the center of molecular biology
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …
considering the unquestionable role of proteins in cells. Combinatorial interactions result in …
The Notch signalling system: recent insights into the complexity of a conserved pathway
KG Guruharsha, MW Kankel… - Nature Reviews …, 2012 - nature.com
Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …
[HTML][HTML] Technical advances in proteomics: new developments in data-independent acquisition
The ultimate aim of proteomics is to fully identify and quantify the entire complement of
proteins and post-translational modifications in biological samples of interest. For the last 15 …
proteins and post-translational modifications in biological samples of interest. For the last 15 …
[HTML][HTML] A protein complex network of Drosophila melanogaster
KG Guruharsha, JF Rual, B Zhai, J Mintseris, P Vaidya… - Cell, 2011 - cell.com
Determining the composition of protein complexes is an essential step toward
understanding the cell as an integrated system. Using coaffinity purification coupled to mass …
understanding the cell as an integrated system. Using coaffinity purification coupled to mass …
Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system
Protein complexes and protein interaction networks are essential mediators of most
biological functions. Complexes supporting transient functions such as signal transduction …
biological functions. Complexes supporting transient functions such as signal transduction …
Accurate protein complex retrieval by affinity enrichment mass spectrometry (AE-MS) rather than affinity purification mass spectrometry (AP-MS)
Protein–protein interactions are fundamental to the understanding of biological processes.
Affinity purification coupled to mass spectrometry (AP-MS) is one of the most promising …
Affinity purification coupled to mass spectrometry (AP-MS) is one of the most promising …
Affinity purification–mass spectrometry and network analysis to understand protein-protein interactions
By determining protein-protein interactions in normal, diseased and infected cells, we can
improve our understanding of cellular systems and their reaction to various perturbations. In …
improve our understanding of cellular systems and their reaction to various perturbations. In …