Retinoids are ubiquitous signaling molecules that influence nearly every cell type, exert
profound effects on development, and complement cancer chemotherapeutic regimens. All …

Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have
potential in the treatment of many other diseases including HIV infection, Alzheimer's …

The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and
anti-inflammatory properties remains challenging in large part owing to the difficulty of …

Protein complexes are responsible for the enactment of most cellular functions. For the
protein complex to form and function, its subunits often need to be present at defined …

Cancer cells are characterized by genetic and epigenetic alterations and phytochemicals,
epigenetic modulators, are considered as promising candidates for epigenetic therapy of …

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-
repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound …

Sin3, a large acidic protein, shares structural similarity with the helix-loop-helix dimerization
domain of proteins of the Myc family of transcription factors. Sin3/HDAC corepressor …

Abstract The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play
essential roles in regulating chromatin accessibility and gene expression. There are two …

The nuclear retinoic acid (RA) receptors (RARα, β and γ) are transcriptional transregulators,
which control the expression of specific gene subsets subsequently to ligand binding and to …

Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen
receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity …