Lyssaviruses cause the disease rabies, which is a fatal encephalitic disease resulting in
approximately 59,000 human deaths annually. The prototype species, rabies lyssavirus, is …

Axons are an essential component of the nervous system, and axon degeneration is an
early feature of many neurodegenerative disorders. The NAD+ metabolome plays an …

SARM1, an executor of axonal degeneration, displays NADase activity that depletes the key
cellular metabolite, NAD+, in response to nerve injury. The basis of SARM1 inhibition and its …

Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been
observed in several nonclinical species, where lesions are characterized by neuronal …

The COVID-19 pandemic reminds us that in spite of the scientific progress in the past
century, there is a lack of general antiviral strategies. In analogy to broad-spectrum …

Aim Multiple sclerosis (MS) is an autoimmune disease, and its typical characteristics are
neuroinflammation and the demyelination of neurons in the central nervous system (CNS) …

Compartmentalized microfluidic neural cell culture platforms, which physically separate
axons from the neural soma using a series of microchannels, have been used for studying a …

Sarbecoviruses such as SARS and SARS-CoV-2 have been responsible for two major
outbreaks in humans, the latter resulting in a global pandemic. While sarbecoviruses …

This review addresses the longstanding debate over whether amyotrophic lateral sclerosis
(ALS) is a 'dying back'or 'dying forward'disorder in the light of new gene identifications and …

Axonal dysfunction and degeneration are important pathological features of central nervous
system (CNS) diseases and traumas, such as Alzheimer's disease, traumatic brain injury …