Diet and microbiota each have a direct impact on many chronic, inflammatory, and metabolic
diseases. As the field develops, a new perspective is emerging. The effects of diet may …

To identify metabolomic reprogramming in early hyperlipidemia, unbiased metabolome was
screened in four tissues from ApoE−/− mice fed with high fat diet (HFD) for 3 weeks. 30, 122 …

The early atherosclerotic lesions develop by the accumulation of arterial foam cells derived
mainly from cholesterol-loaded macrophages. Therefore, cholesterol and cholesteryl ester …

Hyperlipidemia is the most well-known cause of metabolic complications and tissue toxicity
such as liver steatosis, atherosclerosis and obesity. This study aims to evaluate the …

Background: In chronic kidney disease (CKD), cardiovascular morbi-mortality is higher than
in general population. Atherosclerotic cardiovascular disease is accelerated in CKD, but …

Aims: Diabetic nephropathy (DN) is one of the most important causes of chronic renal
disease, and the incidence of DN is increasing worldwide. Considering our previous report …

Mouse models provide powerful tools for studying the mechanisms underlying the
dysfunction of the autonomic reflex control of cardiovascular function and those involved in …

Abstract Background Apoe-deficient (Apoe−/−) mice develop progressive atherosclerotic
lesions with age but no severe renal pathology in the absence of additional challenges. We …

Introduction Hypercholesterolemia contributes as a risk factor for endothelial dysfunction in
the kidneys and worsens the condition of patients with previous kidney damage. This study …

High plasma levels of lipids and/or lipoproteins are risk factors for atherosclerosis,
nonalcoholic fatty liver disease (NAFLD), obesity, and diabetes. These four conditions have …