How to enter a bacterium: bacterial porins and the permeation of antibiotics

JD Prajapati, U Kleinekathöfer… - Chemical …, 2021 - ACS Publications
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Molecular basis of bacterial outer membrane permeability revisited

H Nikaido - Microbiology and molecular biology reviews, 2003 - Am Soc Microbiol
Gram-negative bacteria characteristically are surrounded by an additional membrane layer,
the outer membrane. Although outer membrane components often play important roles in …

A multidisciplinary approach toward identification of antibiotic scaffolds for Acinetobacter baumannii

SP Bhamidimarri, M Zahn, JD Prajapati, C Schleberger… - Structure, 2019 - cell.com
Research efforts to discover potential new antibiotics for Gram-negative bacteria suffer from
high attrition rates due to the synergistic action of efflux systems and the limited permeability …

A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis

SL Rouse, WJ Hawthorne, JL Berry, DS Chorev… - Nature …, 2017 - nature.com
Gram-negative bacteria possess specialised biogenesis machineries that facilitate the
export of amyloid subunits for construction of a biofilm matrix. The secretion of bacterial …

[PDF][PDF] Structure and function of pore-forming b-barrels from bacteria

AH Delcour - J. Mol. Microbiol. Biotechnol, 2002 - caister.com
Crystallographic studies of the past ten years have revealed that many outer membrane
proteins and bacterial toxins are constructed on the b-barrel motif. Two structural classes …

Analysing the outer membrane subproteome of Methylococcus capsulatus (Bath) using proteomics and novel biocomputing tools

FS Berven, OA Karlsen, AH Straume, K Flikka… - Archives of …, 2006 - Springer
High-resolution two-dimensional gel electrophoresis and mass spectrometry has been used
to identify the outer membrane (OM) subproteome of the Gram-negative bacterium …

Mechanism of maltodextrin transport through LamB

PE Klebba - Research in microbiology, 2002 - Elsevier
The Gram-negative bacterial outer membrane contains several independent, biochemically
distinct transport systems for the acquisition of solutes from the environment. Three or more …

[HTML][HTML] The FapF amyloid secretion transporter possesses an atypical asymmetric coiled coil

SL Rouse, F Stylianou, HYG Wu, JL Berry… - Journal of molecular …, 2018 - Elsevier
Gram-negative bacteria possess specialized biogenesis machineries that facilitate the
export of amyloid subunits, the fibers of which are key components of their biofilm matrix …

Structure and functional characterization of the periplasmic N‐terminal polypeptide domain of the sugar‐specific ion channel protein (ScrY porin)

J Michels, A Geyer, V Mocanu, W Welte… - Protein …, 2002 - Wiley Online Library
The structure of the sucrose‐specific porin (ScrY) from Salmonella typhimurium has been
elucidated by X‐ray crystallography to consist of 18 antiparallel β‐strands, associated as a …

Signal sequence mutations as tools for the characterization of LamB folding intermediates

AR Duguay, TJ Silhavy - Journal of bacteriology, 2002 - Am Soc Microbiol
ABSTRACT lamBA23DA25Y and lamBA23YA25Y tether LamB to the inner membrane by
blocking signal sequence processing. We isolated suppressors of lamBA23DA25Y and …