Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …

Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …

Insufficient vessel growth associated with ischemia remains an unresolved issue in vascular
medicine. Mesenchymal stem cells (MSCs) have been shown to promote angiogenesis via a …

Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, eg
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …

Notch signaling is a highly conserved signal transduction pathway that regulates stem cell
maintenance and differentiation in several organ systems. Upon activation, the Notch …

The metabolic adaptation of eukaryotic cells to hypoxia involves increasing dependence
upon glycolytic adenosine triphosphate (ATP) production, an event with consequences for …

The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease characterized
by memory decline and cognitive dysfunction. Although the primary causes of AD are not …