Tetrahydrocurcumin-related vascular protection: An overview of the findings from animal disease models

L Zhang, C Li, S Wang, D Avtanski, N Hadzi-Petrushev… - Molecules, 2022 - mdpi.com
Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-
like pharmacological effects; however, its mechanisms of action are largely unknown. This …

Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with l-NAME-induced hypertension

S Nakmareong, U Kukongviriyapan… - Naunyn-Schmiedeberg's …, 2011 - Springer
Inhibition of nitric oxide synthesis with N ω-nitro-l-arginine methyl ester (l-NAME) induces
marked hypertension and oxidative stress. Curcumin (CUR) has been shown strong …

Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats

M Saravanakumar, B Raja - European Journal of Pharmacology, 2011 - Elsevier
The present study was undertaken to assess the antihypertensive and antioxidant effects of
veratric acid on Nω-nitro-L arginine methyl ester (l-NAME) induced hypertensive rats …

Role of bradykinin in the regulation of endothelial nitric oxide synthase expression by cardiovascular drugs

JB Su - Current pharmaceutical design, 2017 - ingentaconnect.com
NO produced by eNOS plays important roles in the cardiovascular system. Alterations in
eNOS activity and expression occur in various cardiovascular disorders and eNOS …

Study of the mechanism of antihypertensive peptides VPP and IPP in spontaneously hypertensive rats by DNA microarray analysis

N Yamaguchi, K Kawaguchi, N Yamamoto - European journal of …, 2009 - Elsevier
Many antihypertensive effects of angiotensin-I-converting enzyme (ACE) inhibitory peptides
have been studied in spontaneously hypertensive rats (SHRs) and human, however, the …

Green tea could improve elderly hypertension by modulating arterial stiffness, the activity of the renin/angiotensin/aldosterone axis, and the sodium–potassium pumps …

J Gao, A Akbari, T Wang - Journal of Food Biochemistry, 2022 - Wiley Online Library
Hypertension is a major health problem common in the elderly people. Green tea is a
popular beverage recommended in folk medicine for lowering blood pressure. However, the …

eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril

PS Silva, V Fontana, MR Luizon, R Lacchini… - European journal of …, 2013 - Springer
Purpose The antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is
attributed partially to increased nitric oxide bioavailability. It is possible that functional …

The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia

N Soobryan, S Murugesan, W Phoswa… - European journal of …, 2017 - Elsevier
Abstract Pre-eclampsia (PE), a hypertensive disorder of pregnancy, is detrimental to both
mother and foetus. There is currently no effective treatment, but we have shown that …

Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor

DM Abd El Motteleb, SM Elshazly - European journal of pharmacology, 2013 - Elsevier
The present study was undertaken to assess the possible protective effects of sitagliptin, a
dipeptidyl peptidase 4-inhibitor (DPP4), against Nω-nitro-L-arginine methyl ester (L-NAME) …

Impaired vascular function in patients with Fontan circulation

SM Jin, CI Noh, EJ Bae, JY Choi, YS Yun - International journal of …, 2007 - Elsevier
BACKGROUND: This study was performed to evaluate the endothelial function in Fontan
patients, and to investigate the associated factors which influence the endothelial function in …