Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

P Dhyani, C Quispe, E Sharma, A Bahukhandi… - Cancer cell …, 2022 - Springer
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The
treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy …

Role of plant-derived active constituents in cancer treatment and their mechanisms of action

AW Khan, M Farooq, M Haseeb, S Choi - Cells, 2022 - mdpi.com
Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

Mitotic poisons in research and medicine

J Škubník, M Jurášek, T Ruml, S Rimpelová - Molecules, 2020 - mdpi.com
Cancer is one of the greatest challenges of the modern medicine. Although much effort has
been made in the development of novel cancer therapeutics, it still remains one of the most …

[HTML][HTML] Colchicine-capped ZnO nanoparticles: Elucidation of their cytotoxicity potential against MDA-MB 231 cancer cells

Z Cheng, ZY Wong, S Ramkanth, CW Hee, MS TS… - OpenNano, 2024 - Elsevier
This research descibes a pioneering approach aimed at preparing zinc oxide nanoparticles
(ZnO-NPs) with colchicine as the reducing and capping agent. Colchicine-loaded ZnO-NPs …

Design, synthesis, in silico and in vitro evaluation of new combretastatin A-4 analogs as antimitotic antitumor agents

SAA Hussein, A Kubba, AA Balakit… - Medicinal …, 2023 - ingentaconnect.com
Background: Combretastatin A-4 (CA-4) binds β-tubulin at the colchicine-binding site
preventing tubulin from polymerizing into microtubules. CA-4 and cis combretastatin analogs …

PLGA-based nanocarriers for combined delivery of colchicine and purpurin 18 in cancer therapy: Multimodal approach employing cancer cell spheroids

ALV Zumaya, VS Pavlíčková, S Rimpelová… - International Journal of …, 2024 - Elsevier
Improving the anticancer efficacy of chemotherapeutic drugs and photosensitizers requires
innovative multifunctional nanoplatforms. This study introduces a chemo-and …

Composites of Nucleic Acids and Boron Clusters (C2B10H12) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells

D Kaniowski, K Ebenryter-Olbińska, K Kulik… - International Journal of …, 2021 - mdpi.com
Epidermal growth factor receptor (EGFR) is one of the most promising molecular targets for
anticancer therapy. We used boron clusters as a platform for generation of new materials …

[PDF][PDF] Ebenryter-Olbi nska

D Kaniowski - Int. J. Mol. Sci, 2021 - academia.edu
Epidermal growth factor receptor (EGFR) is one of the most promising molecular targets for
anticancer therapy. We used boron clusters as a platform for generation of new materials …

Antioxidant, photoprotective, cytotoxic, and antimicrobial activities of Albuca amoena Batt.

R Zakhour, O El-Guourrami… - Journal of …, 2024 - herbmedpharmacol.com
Abstract Introduction: Albuca amoena Batt. is an endemic plant from Morocco used for
treating melanoma or leishmaniasis. The aim of this study is to test the antioxidant …

Inhibition of MMP2-PEX by a novel ester of dihydroxy cinnamic and linoleic acid from the seagrass Cymodocea serrulata

VS Christina, RL Sundaram, V Sivamurugan… - Scientific Reports, 2021 - nature.com
Matrix metalloproteinases (MMPs) are pivotal for cancer cell migration and metastasis which
are generally over-expressed in such cell types. Many drugs targeting MMPs do so by …