The epithelial mesenchymal transition (EMT) plays a central role in both normal
physiological events (eg, embryonic development) and abnormal pathological events (eg …

▪ Abstract Tight junctions form continuous intercellular contacts controlling solute movement
through the paracellular pathway across epithelia. Paracellular barriers vary among …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

Tight junctions have long been regarded as simple barriers that separate compartments of
different compositions, but recent research indicates that different types of signalling proteins …

The tight junction is an intracellular junctional structure that mediates adhesion between
epithelial cells and is required for epithelial cell function. Tight junctions control paracellular …

Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead
to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because …

Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …

Cell polarity is defined as asymmetry in cell shape, protein distributions and cell functions. It
is characteristic of single-cell organisms, including yeast and bacteria, and cells in tissues of …

Junctional adhesion molecules (JAMs) are members of an immunoglobulin subfamily
expressed by leukocytes and platelets as well as by epithelial and endothelial cells, in which …