Super-resolution microscopy techniques, and specifically single-molecule localization
microscopy (SMLM), are approaching nanometer resolution inside cells and thus have great …

Super-resolution microscopy has profoundly transformed how we study the architecture of
cells, revealing unknown structures and refining our view of cellular assemblies. Among the …

Combining the molecular specificity of fluorescent probes with three-dimensional imaging at
nanoscale resolution is critical for investigating the spatial organization and interactions of …

Three-dimensional single molecule localization microscopy relies on the fitting of the
individual molecules with a point spread function (PSF) model. The reconstructed images …

The synaptonemal complex (SC) is a zipper-like protein assembly that links homologous
chromosomes to regulate recombination and segregation during meiosis. The SC has been …

The current limitations of single-molecule localization microscopy (SMLM) in deep tissue
imaging, primarily due to depth-dependent aberrations caused by refractive index (RI) …

Super-resolution microscopy techniques offer subdiffraction limited resolution that is two-to
ten-fold improved compared to that offered by conventional confocal microscopy. This …

During meiosis, homologous chromosomes must recognize and adhere to one another to
allow for their correct segregation. One of the key events that secures the interaction of …

Faithful chromosome segregation during meiosis requires chromosomes to pair and
recombine with their homologous partners during meiotic prophase I. In most eukaryotes …

Combining the molecular specificity of fluorescent probes with three-dimensional (3D)
imaging at nanoscale resolution is critical for investigating the spatial organization and …