Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells
Immune-based therapies such as immune checkpoint inhibitors have revolutionized the
systemic treatment of various cancer types. The therapeutic application of monoclonal …
systemic treatment of various cancer types. The therapeutic application of monoclonal …
Innate lymphoid cells and innate-like T cells in cancer—at the crossroads of innate and adaptive immunity
Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …
many cancers, yet only a subset of patients benefit from these approaches. A better …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …
performing flow cytometry experiments and includes comprehensive sections describing …
MAIT cell development and functions: the microbial connection
F Legoux, M Salou, O Lantz - Immunity, 2020 - cell.com
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset,
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
MAIT cells regulate NK cell-mediated tumor immunity
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor
immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell …
immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell …
Obesity-mediated immune modulation: one step forward,(Th) 2 steps back
Over the past decades, the relationship between the immune system and metabolism has
become a major research focus. In this arena of immunometabolism the capacity of adipose …
become a major research focus. In this arena of immunometabolism the capacity of adipose …
Engineering human MAIT cells with chimeric antigen receptors for cancer immunotherapy
M Dogan, E Karhan, L Kozhaya, L Placek… - The Journal of …, 2022 - journals.aai.org
Engineering immune cells with chimeric Ag receptors (CARs) is a promising technology in
cancer immunotherapy. Besides classical cytotoxic CD8+ T cells, innate cell types such as …
cancer immunotherapy. Besides classical cytotoxic CD8+ T cells, innate cell types such as …
[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize
microbial vitamin B metabolites and have emerging roles in infectious disease …
microbial vitamin B metabolites and have emerging roles in infectious disease …
Antigen recognition by MR1-reactive T cells; MAIT cells, metabolites, and remaining mysteries
AJ Corbett, W Awad, H Wang, Z Chen - Frontiers in immunology, 2020 - frontiersin.org
Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented
by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors …
by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors …